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anti-Human PARD3 Antibodies:
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Human Polyclonal PARD3 Primary Antibody for ICC, IF - ABIN4343686
Whiteman, Fan, Harder, Walton, Liu, Soofi, Fogg, Hershenson, Dressler, Deutsch, Gumucio, Margolis: Crumbs3 is essential for proper epithelial development and viability. in Molecular and cellular biology 2013
Show all 3 Pubmed References
Studies indicate that the PAR3 (show F2RL2 Antibodies)-PAR6 (show PARD6A Antibodies)-aPKC complex are important for the establishment of neuronal polarity [Review].
that this heterozygotic microdeletion showed no tissue specificity and led to defective expression of PARD3
The authors identified a tumor-suppressive property function of Par3 (show F2RL2 Antibodies) in human cervical cancer and the lost Par3 (show F2RL2 Antibodies) expression may be a marker of poor prognosis.
We first demonstrate that Hook2 (show HOOK2 Antibodies) is essential for the polarized Golgi re-orientation towards the migration front. Depletion of Hook2 (show HOOK2 Antibodies) results in a decrease of PAR6alpha (show PARD6A Antibodies) at the centrosome during cell migration, while overexpression of Hook2 (show HOOK2 Antibodies) in cells induced the formation of aggresomes with the recruitment of PAR6alpha (show PARD6A Antibodies), aPKC and PAR3 (show F2RL2 Antibodies)
elevated expression of Par3 (show F2RL2 Antibodies) promotes PCa (show FLVCR1 Antibodies) metastasis via KIBRA (show WWC1 Antibodies) sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes.
reduced expression of PKCzeta (show PRKCZ Antibodies)/Pard3/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
PARD3 might play a tumor suppressor role in esophageal squamous cell carcinoma.
Loss of Par3 (show F2RL2 Antibodies) promotes metastatic behavior in lung adenocarcinoma cells through 14-3-3zeta (show YWHAZ Antibodies) protein.
Studies suggest that rare deleterious variants of PARD3 in the aPKC-binding region contribute to human cranial neural tube defect (NTD).
These data highlight the importance of the carboxy-terminal motif of the E6 protein and downregulation of PAR3 (show F2RL2 Antibodies) in tumorigenic transformation of human cervical keratinocytes.
radial glial progenitor behavior and cortical development are controlled by temporally distinct actions of partitioning-defective 3 (PARD3) in concert with dynamic HIPPO signaling
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.
HTT (show HTT Antibodies) is required for the apical localization of PAR3 (show F2RL2 Antibodies)-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice.
Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 (show SMEK1 Antibodies) substrate and demonstrate that Smek1 (show SMEK1 Antibodies) suppresses its activity.
Par3 (show F2RL2 Antibodies) (and protein kinase C zeta (show PRKCZ Antibodies)) are activated in neurons when binding to N2-proteoglygan.
Suggest that loss of Par3 (show F2RL2 Antibodies) promotes metastatic behaviour of ErbB2 (show ERBB2 Antibodies)-induced breast tumour epithelial cells by decreasing cell-cell cohesion.
Par3 (show F2RL2 Antibodies) is identified as a regulator of signaling pathways relevant to invasive breast cancer.
The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (show DCTN1 Antibodies) complex, and requires Cdc42 (show CDC42 Antibodies), Par6 (show PARD6A Antibodies) and Par3 (show F2RL2 Antibodies).
Data suggest that aPKC phosphorylates JAM-A (show F11R Antibodies) at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.
Brain-derived neurotrophic factor (BDNF (show BDNF Antibodies)) induces polarized signaling of small GTPase (show RACGAP1 Antibodies) (Rac1 (show RAC1 Antibodies)) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show F2RL2 Antibodies)) protein.
Pard3 mediates contact inhibition between neural crest cells and promotes timely myelin gene expression but is not essential for neural crest migration or myelination.
these results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other processes that involve contact inhibition of locomotion such as cancer invasion or cell dispersion.
Pard3 and Rab11a (show RAB11A Antibodies) are necessary for lumen formation in the neural rod.
Brain-derived neurotrophic factor (BDNF (show BDNF Antibodies)) induces polarized signaling of small GTPase (show RACGAP1 Antibodies) (Rac1 (show RAC1 Antibodies)) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Study demonstrates that the microtubule cytoskeleton gradually transitions from a radial to linear organization during neurulation and that microtubules function in conjunction with the polarity protein Pard3 to mediate centrosome positioning.
Agouti signaling (ASIP) genes exist in many species in lower vertebrates and were most probably present in early stages of vertebrate evolution.
Apical localization of ASIP in neuroepithelial cells involves the oligomerization domain CR1 (show TDGF1 Antibodies), the PDZ (show INADL Antibodies) domains, and the C-terminal portion of the protein.
these results demonstrate a novel role of Par3 (show F2RL2 Antibodies) during neural crest migration, which is likely to be conserved in other processes that involve contact inhibition of locomotion such as cancer invasion or cell dispersion.
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins\; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
CTCL tumor antigen se2-5
, atypical PKC isotype-specific interacting protein
, atypical PKC isotype-specific-interacting protein
, par-3 family cell polarity regulator alpha
, par-3 partitioning defective 3 homolog
, partitioning defective 3 homolog
, atypical PKC-specific binding protein
, atypical PKC-specific-binding protein
, partitioning-defective 3 homolog
, three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)
, partitioning-defective protein 3 homolog
, par-3 partitioning defective 3 homolog (C. elegans)
, ephrin-interacting protein
, partitioning-defective 3 protein
, par-3 family cell polarity regulator S homeolog