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this is the first report showing an association between nectin1 expression and histological subtypes of gastric cancer
Pseudorabies virus infects host cells via both human and swine nectin-1.
In a transgenic mouse line with high expression of nectin-1Ig, significant protection from the infection with 30 and 300 MLD50 was observed .
nectin-1 is expressed in human hair follicles and there is a p63-responsive element in the NECTIN1 promoter
The viral entry receptor Nectin-1 is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells.
HSV gD is able to disrupt intercellular homophilic trans-interaction of nectin-1 and induce a rapid redistribution of nectin-1 from cell junctions.
PVRL1 variants make a contribution to non syndromic Cleft Lip with/without Cleft palate in Turkish patients.
PDZD11 forms a complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif of nectin-1.
mutations in exons 2 and 5 of PVRL1, and T334A, A391T, G1183A in the alpha-spliced transcript, and G1082T in the beta-spliced transcript do not participate in the development of non-syndromic cleft of the lip and/or palate in patients from Guangdong.
data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters.
The results showed that the interface between the BV gD and nectin-1 molecule is not geometrically complementary.
These data provided solid structural and functional evidence that herpes simplex virus 1 and herpes simplex virus 2 gD proteins recognize nectin-1 via the same binding mode.
Authors show that the same key residues in the BC and FG loops of nectin-4 govern binding to the measles virus attachment protein hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1.
Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.
These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation
We identified new supportive evidence that the association between PVRL1 gene and nsCL/P in Turkish patients.
Glycoprotein D (gD) epitope core structure maps to the external surface of herpesvirus (HSV) gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM) and nectin-1, which mediate HSV infection.
The conformation of the N-terminus of herpes simplex virus gD is induced by direct binding to HVEM and nectin-1.
This study demonistated that increased expression of nectin-1 in MS lesions plays a role in the pathogenesis of MS through participation in axonal responses to injury and mediation of altered neuron-glia interactions relevant to myelination.
Nectin-1 Ig3 induced phosphorylation of FGFR1c in the same manner as the whole nectin-1 ectodomain, and promoted survival of cerebellar granule neurons induced to undergo apoptosis.
finding suggests that necroptosis is responsible for GalN/LPS-induced liver injury through DAMP-activated PRR signaling.
Nectin-1 promotes chlamydial infection in the female genital tract but does not appear to contribute to rectal infection in male mice.
nectin-1 regulates the neuronal activities in the CA3 region of the hippocampus.
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development.
The synergistic action of nectins generates mosaic pattern, which cannot be achieved by a single mechanism.
These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb.
Results indicate that the nectin-1 spots constitute a novel adhesion apparatus that tethers mitral cell dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb
results demonstrate a role for both nectin-1 and HVEM as receptors and suggest a further receptor which appears much less efficient.
Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6
In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM can potentially replace nectin-1 as a receptor.
This study demonstrated that nectin1- and nectin3-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration
PRR1 nectin-1 plays a role in the formation of intimal thickening after carotid artery ligation.
Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.
These results suggest that differences in nectin-1 and HVEM receptor expression between adults and newborns may partially explain differences in susceptibility to herpes simplex 2.
Loss of presenilin 1/gamma-secretase activity delays processing of nectin-1 and causes accumulation of its full-length and carboxyl-terminal fragments.
The authors report that either HVEM or nectin-1 must be present for HSV-1 infection of the cornea.
hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia
Results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation.
Nectins asymmetrically localize at puncta adherentia junctions and at synaptic junctions. Inhibition of the nectin-based adhesion by an inhibitor of nectin results in a decrease in synapse size and a concomitant increase in synapse number.
Nectin-1alpha is an immunoglobulin-like receptor involved in the formation of synapses and is a substrate for presenilin/gamma-secretase-like intramembrane proteolytic activity
Contribution of the second and third Ig-like domains of nectin-1 was analysed by generating transgenic mice expressing the entire ectodomain of nectin-1 fused to the porcine Fc portion.
Results demonstrate that a soluble form of the first domain of porcine nectin-1 is able to exert a significant antiviral effect against pseudorabies virus infection.
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
ectodermal dysplasia 4 (Margarita Island type)
, herpes virus entry mediator C
, herpesvirus Ig-like receptor
, nectin 1
, poliovirus receptor-like 1
, poliovirus receptor-related protein 1
, poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
, poliovirus receptor-related 1 (herpesvirus entry mediator C)
, Poliovirus receptor-related protein 1
, herpesvirus entry mediator C
, nectin-1 alpha
, nectin-1 delta
, poliovirus receptor-related 1 (herpesvirus entry mediator C
, poliovirus receptor-related 1
, poliovirus receptor related protein
, nectin 2
, nectin cell adhesion molecule 2 L homeolog
, poliovirus receptor-related 2 (herpesvirus entry mediator B) L homeolog