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Human Polyclonal TLN1 Primary Antibody for ICC, IF - ABIN4357781
Philippe, Léger, Desvaux, Walch: Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells. in The Journal of biological chemistry 2013
Show all 3 Pubmed References
Human Monoclonal TLN1 Primary Antibody for IF, IHC (p) - ABIN2476678
Barlet-Bas, Cheval, Khadouri, Marsy, Doucet: Difference in the Na affinity of Na(+)-K(+)-ATPase along the rabbit nephron: modulation by K. in The American journal of physiology 1990
Show all 4 Pubmed References
Chicken Monoclonal TLN1 Primary Antibody for ICC, FACS - ABIN439404
Longo, Ioannidu, Scotto dAbusco, Superti, Misiano, Zanoni, Politi, Mazzola, Iosi, Mura, Scandurra: Improving Osteoblast Response In Vitro by a Nanostructured Thin Film with Titanium Carbide and Titanium Oxides Clustered around Graphitic Carbon. in PLoS ONE 2016
Human Monoclonal TLN1 Primary Antibody for IHC (p), ELISA - ABIN520958
Lai, Hua, Tsai, Wan, Lin, Chen, Chiu, Chan, Tsai, Jinn-Chyuan Sheu: Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. in The Journal of pathology 2011
Human Polyclonal TLN1 Primary Antibody for ELISA, WB - ABIN4357780
Manevich, Grabovsky, Feigelson, Alon: Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. in The Journal of biological chemistry 2007
Talin-1 induces proliferation and migration of vascular smooth muscle cells obtained from patients with thoracic aortic dissection.
Here, the authors show that cortical microtubule stabilization sites containing CLASPs, KIF21A (show KIF21A Antibodies), LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1 (show ANKRD15 Antibodies), which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 (show ANKRD15 Antibodies) binds to the talin rod domain R7.
Vinculin (show VCL Antibodies) head-tail interaction is required on soft substrates to destabilize vinculin (show VCL Antibodies) and talin in FAs (show FAS Antibodies), and to allow hMSCs branching. Another module involves paxillin (show PXN Antibodies) and FAK (show PTK2 Antibodies), which soft substrates also destabilize, but independently of vinculin (show VCL Antibodies) head-tail interaction. This multi-modularity may be key to allow a versatile response to complex biomechanical cues.
The central role of talin and vinculin (show VCL Antibodies) in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (show MMRN1 Antibodies) interactions and remodeling of the tissue.
Application of these techniques to new talin biosensors reveals an intramolecular tension gradient across talin-1 that is established upon integrin-mediated cell adhesion. The tension gradient is actomyosin- and vinculin (show VCL Antibodies)-dependent and sensitive to the rigidity of the extracellular environment
Our findings confirm the role of Talin-1 in carcinogenesis and provided a set of novel therapeutic targets for the treatment of hepatocellular carcinoma
These data show that TLN1 can act as a viral restriction factor that suppresses hepatitis B virus replication, and suggest that the HBx relieves this restriction by inducing TLN1 degradation.
The ERK (show EPHB2 Antibodies) pathway was responsible for these promoting effects of Talin1 knockdown in HCC (show FAM126A Antibodies) cells.
This study showed that serum sTalin-1 levels were associated with a sustained increase in disability after MS attack but not with serum anti-Talin-1 antibody levels.
The Rap1 (show RABGEF1 Antibodies)-RIAM (show APBB1IP Antibodies)-talin axis of integrin activation and blood cell function
SKAP1 (show SKAP1 Antibodies) can affect the function of talin in T-cells needed for optimal T-cell/dendritic cell conjugation
FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Antibodies) binding and adhesion.
Binding of vinculin (show VCL Antibodies) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 (show TLN2 Antibodies) modulates extracellular rigidity sensing.
Conformational activation of talin by PREL-1 (show APBB1IP Antibodies) triggers integrin-mediated cell adhesion.
Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures.
reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM (show APBB1IP Antibodies) binding and exposes the vinculin (show VCL Antibodies) binding sites, which recruit vinculin (show VCL Antibodies) to stabilize the complex.
Talin1 has unique expression versus talin 2 (show TLN2 Antibodies) in the heart and modifies the hypertrophic response to pressure overload.
suggest that Tln1-mediated Itgbeta1b plays a crucial role in maintaining cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity in zebrafish
CD90 (Thy1 (show THY1 Antibodies)) is a novel interactor of talin 1 in effector cells of autoimmune equine uveitis.
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
, talin 1
, Talin 1