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anti-Mouse (Murine) WNT11 Antibodies:
anti-Human WNT11 Antibodies:
anti-Rat (Rattus) WNT11 Antibodies:
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In midgastrula embryos, Wnt5a (show WNT5A Antibodies), Wnt11, and Wnt11b, but not Wnt3a (show WNT3A Antibodies), acted across many cell diameters to orient Prickle3 (show PRICKLE3 Antibodies)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
PAR-1 (show F2R Antibodies) RNA rescues neural cell markers in embryos in which noncanonical Wnt (show WNT2 Antibodies) signaling has been blocked. Novel roles for Wnt11R and PAR-1 (show F2R Antibodies) were identified in neural cell specification. An unexpected connection was shown between morphogenesis and cell fate.
Xenopus Wnt11-R is expressed in neural tissue, the brachial arches, and the muscle layer of the heart.
Wnt11-R signaling regulates a calcium sensitive EMT (show ITK Antibodies) event essential for dorsal fin development of Xenopus.
wnt11r is required in a non-cell-autonomous manner to control neural crest migration.
These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development.
Wnt4 (show WNT4 Antibodies) and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation.
Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis.
under tensile stress, miR (show MLXIP Antibodies)-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt (show WNT2 Antibodies)/PCP (show BMP1 Antibodies) pathway by directly targeting Wnt11
a mechanistic link between E-cadherin (show CDH1 Antibodies) loss and subsequent control of Rho-driven anoikis resistance through p120 (show CTNND1 Antibodies)- and Kaiso (show ZBTB33 Antibodies)-dependent expression of Wnt11, is reported.
Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs (show NR2E3 Antibodies) & found differential gene expression patterns for Wnt5a (show WNT5A Antibodies) & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes.
Data show that Wnt5a (show WNT5A Antibodies) and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation.
These results provide formal genetic proof that the majority of the endocardium and myocardium diverge by mid-gastrulation in the mouse, and suggest a tight spatial and temporal control of Wnt11 expression in the myocardial lineage.
Wnt5a (show WNT5A Antibodies)/Wnt11 inhibit beta-catenin (show CTNNB1 Antibodies) to promote SHF (show SHF Antibodies) development through Caspase (show CASP3 Antibodies)-dependent Akt (show AKT1 Antibodies) degradation
Notch1 (show NOTCH1 Antibodies)-induced WISP-1 (show WISP1 Antibodies) expression appeared to be Wnt11-dependent, but Wnt1 (show WNT1 Antibodies)-independent
we found that the hypoxic environment of the perivenular zone promotes Wnt11 expression in hepatocytes, which then regulates unique gene expression via activation of the non-canonical Wnt (show WNT2 Antibodies) pathway
Noncanonical Wnt (show WNT2 Antibodies) signaling via Wnt5a (show WNT5A Antibodies)/5b/11 may have role in the pathogenesis of aortic valve calcification.
TGF-beta1-induced sm-alpha-actin expression is mediated by WNT-11 via RhoA activation and subsequent actin cytoskeletal remodeling.
The positive rates of Wnt11 protein in normal esophageal epithelium tissue was 29.8% and in esophageal carcinomas tissue was 31.9%; there was no significant difference between the two groups
Data suggest that Wnt-11 may serve as a target for cervical cancer therapy.
The Wnt11 gene plays an important role in human mesenchymal stromal cells for enhancing the osteogenesis in an infectious environment.
Demonstrate immunohistochemical expression of Wnt11 and BCL2A1 (show BCL2A1 Antibodies) in complete moles and normal villi.
Report high expression of Wnt11 in esophageal squamous cell carcinoma, which was significantly associated with AJCC stage.
High expression of Wnt-11 is associated with metastasis in cervical cancer.
data suggest an important role of Ror2 (show ROR2 Antibodies) in mediating Wnt11 signaling and in regulating convergence and extension movements in zebrafish.
Swap70b and Def6a (show DEF6 Antibodies) delineate Wnt11 and Wnt5b (show WNT5B Antibodies) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
CTCF (show CTCF Antibodies) acts upstream of wnt11 during zebrafish muscle development.
findings provide the first evidence that wnt11 itself is a downstream target of the Jnk (show MAPK8 Antibodies) cascade in the non-canonical Wnt (show WNT2 Antibodies) pathway
data reveal a previously unrecognized role for Wnt (show WNT2 Antibodies)/Ca(2 (show CA2 Antibodies)+) signalling in establishing an electrical gradient in the plane of the developing cardiac epithelium through modulation of ion-channel function
Wnt11 and Prickle1a are expressed in the dorsal forerunner cells and regulate Kupffer's vesicle morphogenesis.
three Wnt (show WNT2 Antibodies) noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
wnt11 and Fz5 signaling promotes early eye development through the coordinated antagonism of signals that suppress retinal identity
Results suggest that Wnt11 controls tissue morphogenesis by modulating E-cadherin (show CDH1 Antibodies)-mediated cell cohesion through Rab5c (show Rab5c Antibodies), a novel mechanism of Wnt (show WNT2 Antibodies) signaling in gastrulation.
with combined loss of Tbx16 and Wnt11 (Silberblick), coalesence is essentially absent. Possibly as a consequence, both the anterior movement of presumptive prechordal plate and organizer function, as assayed by eye-field separation, are disrupted.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.
, WNT11-related protein
, protein Wnt-11-related
, wingless-type MMTV integration site family, member 11
, protein Wnt-11b-2
, protein Wnt-11-like
, Wnt-11 protein
, wingless-related MMTV integration site 11