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Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.
Data indicate that PAQR4 has a tumorigenic effect on human breast cancers, and such effect is associated with a modulatory activity of PAQR4 on protein degradation of CDK4
MiR (show MLXIP Proteins)-340 overexpression inhibited tumor growth by regulating CDK4 expression. miR (show MLXIP Proteins)-340 functions as a tumor suppressor in non small cell lung cancer (NSCLC) cells and may provide a potential target of NSCLC treatment.
CDK4 and XPO1 (show XPO1 Proteins) are not altered in a rare undifferentiated sarcoma, making them therapeutic targets
while mTOR inhibitors restore endocrine sensitivity, CDK4/6 inhibitors may favor the emergence of estrogen receptor 1 (ESR1) mutations resulting in ligand-independent activity of the receptor
Inhibition of CDK4/6 is potentially a highly effective strategy for the treatment of SHH (show SHH Proteins) and MYC (show MYC Proteins)-amplified group 3 medulloblastoma.
SOX12 (show SOX12 Proteins) can increase the expression of CDK4 and IGF2BP1 (show IGF2BP1 Proteins), which confer malignant phenotypes to Hepatocellular Carcinoma.
Study showed that CDK4 and BCAS2 (show BCAS2 Proteins) may be target genes of miR (show MLXIP Proteins)-486 and levels of CDK4 and BCAS2 (show BCAS2 Proteins) were both significantly higher in the esophageal cancer tissues and cell lines than levels in the normal tissues and cells.
Results suggest that dysregulation and activation of the cell cycle proteins CDK4/CDK6 (show CDK6 Proteins)-CCND1 (show CCND1 Proteins)-phospho-RB1 (show RB1 Proteins) axis is associated with higher proliferative index in neuroendocrine tumors (NETs).
blocking CDK4 activity efficiently eliminated both normal and chemotherapy-resistant cancer cells in triple negative breast cancers, highlighting CDK4 as a promising novel therapeutic target for these aggressive breast tumors.
Amplification of gene CDK4 is associated with lung adenocarcinoma.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (show GJA1 Proteins) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
CDK4/CDK6 (show CDK6 Proteins)-dependent activation of DUB3 (show USP17L2 Proteins) regulates cancer metastasis through SNAIL1 (show SNAI1 Proteins).
Study examined proliferation rates of cortical progenitor cells in mice lacking individual cdk proteins or combinations thereof. Results provide evidence that concomitant loss of cdk4 and cdk6 (show CDK6 Proteins) leads to reduced proliferation rates specifically in basal progenitor cells in both the dorsal and ventral forebrain. Cdk4-/-;Cdk6 (show CDK6 Proteins)-/- double mutant progenitor cells in the dorsal telencephalon exhibit accelerated cell cycle exit.
These results indicate that p18 (show CDKN2C Proteins) blocks reprogramming by targeting Cdk4/6-mediated cell cycle regulation.
Activation of cdk4 triggers NAFLD.
This novel mechanism explains how CDK4 promotes anabolism by blocking catabolic processes (FAO) that are activated by AMPK (show PRKAA1 Proteins).
PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.
The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (show SOD2 Proteins).
a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN
Our data indicate that Cdk2 (show CDK2 Proteins) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.
CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (show NRF1 Proteins) and consequent induction of Tfam (show TFAM Proteins) and mitochondrial ribossomal transcription.
Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos
mRpL12 (show MRPL12 Proteins) is required for CycD/Cdk4-induced cell growth
Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
cell division protein kinase 4
, cyclin dependent kinase 4
, serine/threonine kinase
, Cell division protein kinase 4
, Cyclin-dependent kinase 4/6
, cyclin-dependent kinase 4
, protein kinase-like 53C