CDK5 Proteins

17 Cyclin-Dependent Kinase 5 (CDK5) Proteins from 8 manufacturers are available on www.antibodies-online.com.

Data Quality
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Type
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    Protein
Antigen
  • 17
Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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  • 5
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Protein Type
  • 17
Format
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Suggested next Filters
17 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3090892
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3134259
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1348956
$340.00
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Insect Cells (Source)
ReactivityHuman
Application Func, SDS
Order details Cat. No. ABIN5570449
$516.00
5 μg
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 85 % pure
ReactivityHuman
Application SDS
Order details Cat. No. ABIN2128476
$431.00
100 μg
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1348958
$340.00
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1348960
$340.00
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivityHuman
Application SDS
Order details Cat. No. ABIN5709263
$456.50
Plus shipping costs $45.00
Will be delivered in 11 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 85 % by SDS - PAGE
ReactivityHuman
Application SDS
Order details Cat. No. ABIN1098713
$553.85
Plus shipping costs $45.00
Delivery in 15 to 19 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2713865
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity > 90 % by SDS - PAGE
ReactivityHuman
Application SDS
Order details Cat. No. ABIN6388118
$1,384.62
Plus shipping costs $45.00
Delivery in 13 to 16 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity > 94 % as determined by SDS-PAGE
ReactivityHuman
Application SDS
Order details Cat. No. ABIN2003568
ISO
$233.59
50 μg
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivityHuman
Application Imm, PC, SDS, WB
Order details Cat. No. ABIN6238300
$350.00
50 μg
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN1170271
$560.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source)
ReactivityRat (Rattus)
Application SDS, WB
Order details Cat. No. ABIN6122177
$590.93
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
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CDK5 Protein Profile

Protein Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin dependent kinase 5 (CDK5) antibody
  • cyclin-dependent kinase 5 (Cdk5) antibody
  • Cyclin-dependent kinase 5 (Cdk5) antibody
  • cyclin-dependent kinase 5 (cdk5) antibody
  • cyclin-dependent kinase 5 L homeolog (cdk5.L) antibody
  • cyclin dependent kinase 5 (Cdk5) antibody
  • Cyclin-dependent-like kinase 5 (cdk-5) antibody
  • AW048668 antibody
  • cdk5 antibody
  • CG8203 antibody
  • Crk6 antibody
  • DmCdk5 antibody
  • Dmel\\CG8203 antibody
  • PSSALRE antibody
  • zgc:101604 antibody

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , CG8203-PA , Cdk5-PA , PDPK , proline-directed protein kinase 33 kDa subunit , neuronal cyclin-dependent kinase 5 , Cell division protein kinase 5 , cyclin-dependent-like kinase 5

GENE ID SPECIES
1020 Homo sapiens
12568 Mus musculus
36727 Drosophila melanogaster
140908 Rattus norvegicus
281066 Bos taurus
65234 Danio rerio
399296 Xenopus laevis
100190948 Gallus gallus
475537 Canis lupus familiaris
100732840 Cavia porcellus
100190973 Ovis aries
733700 Sus scrofa
100352775 Oryctolagus cuniculus
176774 Caenorhabditis elegans
101865873 Macaca fascicularis