CDK5 Protein (GST tag)
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- Target See all CDK5 Proteins
- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This CDK5 protein is labelled with GST tag.
- Purpose
- Recombinant Human CDK5 Protein (GST Tag)
- Sequence
- Met 1-Pro 292
- Characteristics
- A DNA sequence encoding the human CDK5 isoform 1 (NP_004926.1) (Met 1-Pro 292) was fused with the GST tag at the N-terminus.
- Purity
- > 94 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CDK5 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, 0.5 mM GSH, pH 7.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
- Alternative Name
- CDK5 (CDK5 Products)
- Synonyms
- PSSALRE Protein, AW048668 Protein, Crk6 Protein, CDK5 Protein, CG8203 Protein, DmCdk5 Protein, Dmel\\CG8203 Protein, cdk5 Protein, zgc:101604 Protein, cyclin dependent kinase 5 Protein, cyclin-dependent kinase 5 Protein, Cyclin-dependent kinase 5 Protein, cyclin-dependent kinase 5 L homeolog Protein, Cyclin-dependent-like kinase 5 Protein, CDK5 Protein, Cdk5 Protein, cdk5 Protein, cdk5.L Protein, cdk-5 Protein
- Background
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Background: Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by CDK5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. CDK5, unlike other Cdks, is not regulated by cyclins, and its activity is primarily detected in postmitotic neurons in developing and adult nervous systems. CDK5 is activated by association with a neuron-specific activator, p35 or its isoform p39. CDK5 is probably involved in the control of the cell cycle. It interacts with D1 and D3-type G1 cyclins. CDK5 can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. It also interacts with p35 which activates the kinase. CDK5 plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death.
Synonym: PSSALRE
- Molecular Weight
- 59.6 kDa
- NCBI Accession
- NP_004926
- Pathways
- Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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