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Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway.
AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2-mediated degradation so as to prevent foam cell formation
CSN2 knockdown cells underwent non-apoptotic cell death.
p300 binds to Alien alpha by pull down (View interaction) Alien alpha physically interacts with CBP by two hybrid
demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2
Alien and Sin3A reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24) promoter containing vitamin D3 response elements by chromatin immunoprecipitation
Data show that Alien binds in vivo and in vitro to NAP1 and modulates its activity by enhancing NAP1-mediated nucleosome assembly on DNA.
Protein interactions of Alien involving nucleophosmin, ERCC3, TRIP11, as well as CRSP3.
Alien inhibits E2F1 gene expression and cell proliferation.
the interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network
CSN2 gene was identified in the genome-wide loss-of-function genetic screen as putative tumor suppressor located at 15q21.2.
Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly.
A subunit of the COP9 signalosome interacted physically with the anaphase-promoting complex and showed a genetic instability of cells.
Cops2, but not the whole COP9 signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance.
these data indicate that Alien/ESET complex is involved in TRbeta1-mediated transcription repression of E2F1 and provide a molecular basis of thyroid hormone-induced repression of proliferation.
Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2.
Expressed at an early stage of neuronal differentiation of P19 embryonal carcinoma cells.
Disruption of Cops2 causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
transcriptional corepressor that may be involved in neural differentiation
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
, COP9 signalosome complex subunit 2
, COP9 constitutive photomorphogenic homolog subunit 2
, JAB1-containing signalosome subunit 2
, TR-interacting protein 15
, alien homolog
, signalosome subunit 2
, thyroid receptor interacting protein 15
, thyroid receptor-interacting protein 15
, COP9 (constitutive photomorphogenic) homolog, subunit 2
, tyroid receptor interacting protein 15
, COP9 constitutive photomorphogenic homolog subunit 2-like
, COP9 signalosome complex subunit 2-like
, COP9 (constitutive photomorphogenic, subunit 2
, alien homologue
, COP9 constitutive photomorphogenic-like subunit 2