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Data indicate that DET1- and DDB1-associated protein 1 (DDA1 (show DDA1 Proteins))-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB (show NFKB1 Proteins))/COP9 (show COPS8 Proteins) signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway.
AIBP (show APOA1BP Proteins) promotes apoA-1 (show APOA1 Proteins) binding to ABCA1 (show ABCA1 Proteins) on the cell membrane of macrophages and prevents ABCA1 (show ABCA1 Proteins) protein from CSN2 (show CSN2 Proteins)-mediated degradation so as to prevent foam cell formation
CSN2 (show CSN2 Proteins) knockdown cells underwent non-apoptotic cell death.
p300 (show EP300 Proteins) binds to Alien alpha by pull down (View interaction) Alien alpha physically interacts with CBP (show CREBBP Proteins) by two hybrid
demonstrate Alien-MLK2 (show MAP3K10 Proteins) interaction and also show that MLK2 (show MAP3K10 Proteins) is able to phosphorylate Alien; Alien, DAX-1 (show NR0B1 Proteins) and thyroid hormone receptor (show THRA Proteins) mediated transcriptional silencing is strongly enhanced in the presence of active MLK2 (show MAP3K10 Proteins)
Alien and Sin3A (show SIN3A Proteins) reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24 (show CYP24A1 Proteins)) promoter containing vitamin D3 response elements by chromatin immunoprecipitation
Data show that Alien binds in vivo and in vitro to NAP1 (show IL8 Proteins) and modulates its activity by enhancing NAP1 (show IL8 Proteins)-mediated nucleosome assembly on DNA.
Protein interactions of Alien involving nucleophosmin (show NPM1 Proteins), ERCC3 (show ERCC3 Proteins), TRIP11, as well as CRSP3 (show MED23 Proteins).
Alien inhibits E2F1 (show E2F1 Proteins) gene expression and cell proliferation.
the interaction between Alien and the tumor suppressors p33ING1 (show ING1 Proteins) and p33ING2 (show ING2 Proteins) reveals a novel cellular protein network
Cops2, but not the whole COP9 (show COPS8 Proteins) signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance.
these data indicate that Alien/ESET (show SETDB1 Proteins) complex is involved in TRbeta1 (show THRB Proteins)-mediated transcription repression of E2F1 (show E2F1 Proteins) and provide a molecular basis of thyroid hormone (show PTH Proteins)-induced repression of proliferation.
Nif3l1 participates in neural differentiation of P19 (show CDKN2D Proteins) cells through cooperation with Trip15/CSN2.
Expressed at an early stage of neuronal differentiation of P19 embryonal carcinoma cells.
Disruption of Cops2 causes deficient cell proliferation, accumulation of p53 (show TP53 Proteins) and cyclin E (show CCNE1 Proteins), and early embryonic death.
transcriptional corepressor that may be involved in neural differentiation
COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
, COP9 signalosome complex subunit 2
, COP9 constitutive photomorphogenic homolog subunit 2
, JAB1-containing signalosome subunit 2
, TR-interacting protein 15
, alien homolog
, signalosome subunit 2
, thyroid receptor interacting protein 15
, thyroid receptor-interacting protein 15
, COP9 (constitutive photomorphogenic) homolog, subunit 2
, tyroid receptor interacting protein 15
, COP9 constitutive photomorphogenic homolog subunit 2-like
, COP9 signalosome complex subunit 2-like
, COP9 (constitutive photomorphogenic, subunit 2
, alien homologue
, COP9 constitutive photomorphogenic-like subunit 2