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Browse our anti-COPS6 (COPS6) Antibodies

Full name:: anti-COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) Antibodies (COPS6)

On www.antibodies-online.com are 52 COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) Antibodies from 14 different suppliers available. Additionally we are shipping COPS6 Proteins (14) and many more products for this protein. A total of 69 COPS6 products are currently listed.

Synonyms:: CG6932, CH6, CSN6, Dch6, Dmel\\CG6932, MOV34-34KD, Sgn3, VIP/MOV34, zgc:112075

list all antibodies	Gene Name	GeneID	UniProt
	COPS6	304343
	COPS6	26893	O88545
	COPS6	10980	Q7L5N1
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Most Popular Reactivities for anti-COPS6 (COPS6) Antibodies

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anti-Rat (Rattus) COPS6 Antibodies:

anti-Mouse (Murine) COPS6 Antibodies:

anti-Human COPS6 Antibodies:

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Relevant Pathways for anti-COPS6 Antibodies

Cell Division Cycle

More product categories related to COPS6 Antibody

Top referenced anti-COPS6 Antibodies

Cow (Bovine) Polyclonal COPS6 Primary Antibody for WB - ABIN2788037 : Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. in PLoS ONE 2012 (PubMed)
Human Polyclonal COPS6 Primary Antibody for ICC, IF - ABIN4300068 : Scimeca, Piccirilli, Mastrangeli, Rao, Feola, Orlandi, Gasbarra, Bonanno, Tarantino: Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia. in Journal of translational medicine 2017 (PubMed)

More Antibodies against COPS6 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

the 2.5A crystal structure of MPN domain from Drosophila melanogaster CSN6.

Zebrafish COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

Findings indicate that cops6 plays an anti-apoptotic role during segmentation.

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis.
results define a mechanism for the regulation of Myc stability through the CSN-Cullin-Fbxw7 axis and provide insights into the correlation of CSN6 overexpression with Myc stabilization/activation during tumorigenesis
loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway

Human COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) interaction partners

High CSN6 expression is associated with metastasis of glioblastoma.
The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells.
CSN6 positively regulates c-Jun in a MEKK1-dependent manner
our results indicate that CSN6 is a positive regulator of E6AP and is important for cervical cancer development.
CSN6 interacts with p27(Kip1) and facilitates ubiquitin-mediated degradation of p27(Kip1).
Findings indicate that the deregulation of beta-catenin by extracellular signal-regulated kinase 2 (ERK2)-activated CSN6 protein is important for colorectal cancer (CRC) development.
Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.
Data suggest that CSN6 is an important negative regulator of p57 (Kip2) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2) and result in promoted cancer cell growth.
COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway
critical role of caspase 8 in the processing of CSN6.
For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process.

COPS6 Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

Alternative names and synonyms associated with COPS6

COP9 signalosome subunit 6 (COPS6) antibody
COP9 signalosome subunit 6 (Cops6) antibody
COP9 signalosome subunit 6 (CSN6) antibody
COP9 signalosome subunit 6 (cops6) antibody
COP-9 SigNalosome subunit (csn-6) antibody

CG6932 antibody
CH6 antibody
CSN6 antibody
Dch6 antibody
Dmel\\CG6932 antibody
MOV34-34KD antibody
Sgn3 antibody
VIP/MOV34 antibody
zgc:112075 antibody

Protein level used designations for COPS6

COP9 (constitutive photomorphogenic) homolog, subunit 6 , COP9 constitutive photomorphogenic homolog subunit 6 , COP9 signalosome complex subunit 6 , CG6932-PA , CSN6-PA , drosophila COP9 signalosome homolog 6 , COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) , COP9 (constitutive photomorphogenic), subunit 6 , COP9 complex S6 , JAB1-containing signalosome subunit 6 , SGN6 , signalosome subunit 6 , COP9 signalosome subunit 6 , COP9 subunit 6 (MOV34 homolog, 34 kD) , H_NH0506M12.12 , MOV34 homolog, 34 kD , hVIP , vpr-interacting protein

GENE ID	SPECIES
479738	Canis lupus familiaris
304343	Rattus norvegicus
42661	Drosophila melanogaster
463587	Pan troglodytes
550465	Danio rerio
26893	Mus musculus
512756	Bos taurus
100125954	Sus scrofa
100171609	Pongo abelii
10980	Homo sapiens
178289	Caenorhabditis elegans

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Show all anti-COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) (COPS6) Antibodies with Pubmed References