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anti-Human Cyclin H Antibodies:
anti-Mouse (Murine) Cyclin H Antibodies:
anti-Rat (Rattus) Cyclin H Antibodies:
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Human Monoclonal Cyclin H Primary Antibody for IF, IHC (p) - ABIN560218
Nakazawa, Sasaki, Mitsutake, Matsuse, Shimada, Nardo, Takahashi, Ohyama, Ito, Mishima, Nomura, Kinoshita, Ono, Takenaka, Masuyama, Kudo, Slor, Utani, Tateishi, Yamashita, Stefanini, Lehmann, Yoshiura et al.: Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. ... in Nature genetics 2012
Cyclin H is implicated in the regulation of the transcriptional machinery during midblastula transition and is therefore an essential gene in early zebrafish larval development.
Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97
Genetic polymorphisms in cyclin H gene are associated with oxaliplatin-induced acute peripheral neuropathy in South Indian digestive tract cancer patients.
Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer.
Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
SNPs in CCNH and ABCG2 can modulate the development of severe oxaliplatin-induced peripheral neuropathy.
Hemodynamic forces modulate EC proliferative phenotype through the miR-23b/CAK/cyclin H pathway.
When considering all thyroid cancer (DTC) cases, only rs2230641 (CCNH) was associated with DTC risk.
CCNH and CDK7 may play an important role in the tumorigenesis and development of esophageal squamous cell carcinoma.
High Cyclin H is associated with gastrointestinal stromal tumours.
The expression of cyclin H and CDK7 protein in proliferating hemangiomas was significantly higher than that in involuting hemangiomas and normal skin tissues.
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Confocal microscopy revealed the co-localization of PKC-iota with CAK/cdk7 in both the cytoplasm and nucleus of U-373 MG glioma cells, supporting its role in cell signaling
In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha
Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling.
These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins.
Our study demonstrates the independent prognostic value of cyclin H expression in diffuse large B-cell lymphoma and proposes its use as a prognostic marker.
TFIIH changes subunit composition in response to DNA damage. The CAK is released from the core during nucleotide excision repair (NER).
CDK7 and CCNH activate CDC2 by T161 phosphorylation and make up CDK-activating kinase, which is required for normal meiotic progression during porcine oocyte maturation.
investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
, cyclin h
, Cyclin H
, cyclin H
, CYclin H family member (cyh-1)
, CAK complex subunit
, CDK-activating kinase complex subunit
, MO15-associated protein
, cyclin-dependent kinase-activating kinase complex subunit