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anti-Mouse (Murine) GADD45G Antibodies:
anti-Human GADD45G Antibodies:
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Human Monoclonal GADD45G Primary Antibody for IF, IHC - ABIN2721558
Hsu, Chen, Huang: Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45? in human brain malignant glioma (GBM) 8401 cells. in Cell death & disease 2014
Show all 3 Pubmed References
Human Polyclonal GADD45G Primary Antibody for ELISA - ABIN314291
Zerbini, Wang, Czibere, Correa, Cho, Ijiri, Wei, Joseph, Gu, Grall, Goldring, Zhou, Libermann, Zhou: NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. in Proceedings of the National Academy of Sciences of the United States of America 2004
Human Monoclonal GADD45G Primary Antibody for ELISA, WB - ABIN564735
Scuto, Kirschbaum, Kowolik, Kretzner, Juhasz, Atadja, Pullarkat, Bhatia, Forman, Yen, Jove: The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. in Blood 2008
PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression.
accumulation during myocardial infarction promotes the development and persistence of heart failure by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner
Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity
The Gadd45g-d4Venus mice exhibited very similar labeling patterns in the ventricular zone (VZ), in Gadd45g-d4Venus mice cells could be visualized in more basal areas containing fully differentiated neurons.
Identify growth arrest and DNA-damage-inducible protein 45 gamma (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in brown adipose tissue.
GADD45G functions as a negative regulator of the Jak-Stat3 pathway and inhibits hepatocellular carcinoma by inducing cellular senescence.
Gadd45g as a candidate gene for male infertility and 46,XY sex reversal in humans
suggest a requirement for GADD45gamma in promoting MAP3K4-mediated activation of p38 MAPK signaling in embryonic gonadal somatic cells for testis determination
suggest that a signaling cascade, involving GADD45G --> p38 MAPK --> GATA4 --> SRY, regulates male sex determination
Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
Results identify Gadd45gamma as a direct transcriptional target of Ascl1.
members of the Gadd45 gene family are important for anti-tumor immune responses.
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
are induced by acute hypertonicity in murine kidney collecting duct cells.
localization of the Gadd45g gene to mouse chromosome band 13A5-B, which has been reported to contain a quantitative trait locus that regulates body weight
During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented interferon-gamma production in a process independent of STAT4.
Gadd45gamma induction strongly potentiates apoptosis
Gadd45gamma plays a critical role in the resolution of immune responses that prevent autoimmunity
The crystal structure of Gadd45gamma, which reveals a fold comprising an alphabetaalpha sandwich with a central five-stranded mixed beta-sheet with alpha-helices packed on either side, is reported.
In an Eastern Chinese population, carriers of GADD45G rs8252T variant genotypes had a significantly lower risk of NSCLC. rs8252 variant CT/TT carriers showed significantly higher levels of GADD45G mRNA expression than CC carriers in the target tissues. There was some evidence of interactions between rs8252 genotypes and sex in NSCLC risk.
In addition to changes in MEK3 gene regulation, our study demonstrated upregulation of CACNG2 and GADD45G at the mRNA level in CMM patients.
In contrast to solid tumors, in DLBCL, the frequency of GADD45gamma methylation is higher and may be associated with progression. Nodal involvement is more likely to be present in patients with unmethylated GADD45gamma.
GADD45G protein, human
Results establish that the dowregulation of GADD45G-SIP1 axis may contribute to cellular senescence evasion and HCC development.
we demonstrated that GADD45gamma expression in hepatocellular carcinoma cells was associated with sorafenib sensitivity
demonstrate for the first time that miR-383 can specifically regulates the expression of Gadd45g by directly targeting to the 3-UTR region of Gadd45g mRNA, a regulatory process conserved in human tumor cells and mouse embryonic stem cells
Expression of GADD45gamma was significantly higher in pituitary adenomas of female patients.
Suggest that cucurbitacin E induced mitosis delay is regulated by GADD45gamma overexpression in malignant gliomas.
The gadd45g gene has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event. (Review)
Decreased expression and aberrant methylation of Gadd45G is associated with tumor progression in esophageal squamous cell carcinoma.
Methylation-mediated repression of GADD45G expression is associated with gastric cardia adenocarcinoma.
In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample.
Knock-down of GADD45gamma significantly attenuates TNF-a and IL-6 production in the human monocyte-macrophage THP-1 cell line as well as in human peripheral blood mononuclear cells
clinically non-functioning adenomas had a significant decrease (P<0.001) in the relative levels of GADD45c expression (13 of 14 adenomas or 92%), compared to functioning adenomas (11 of 24 or 46%)
Data show that mda-7/IL-24 activation leads to upregulation of growth arrest and DNA damage inducible (GADD) 45 alpha and gamma and JNK activation.
These results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function
The induction of GADD45gamma gene expression by 1,25-(OH)2D3 may mark therapeutic response in prostate cancer.
Here, the full-length cDNA sequence of porcine GADD45G gene was cloned through rapid amplification of cDNA ends (RACE) method.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
, growth arrest and DNA damage 45 gamma
, growth arrest and DNA damage-inducible protein GADD45 gamma
, growth arrest and DNA-damage-inducible, gamma
, cytokine-responsive protein CR6
, growth arrest and DNA-damage-inducible protein GADD45 gamma
, DNA damage-inducible transcript 2 protein
, gadd-related protein, 17 kD
, growth arrest and DNA damage inducible
, growth arrest and DNA-damage-inducible 45 gamma
, growth arrest and DNA-damage-inducible gamma protein