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Human POT1 Protein expressed in HEK-293 Cells - ABIN2729370
Choi, Lakamp-Hawley, Kolar, Yan, Borgstahl, Ouellette: The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs. in Biochimie 2015
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A defective POT1-TPP1 (show TPP1 Proteins) complex leads to longer and fragile telomeres, which in turn promotes genomic instability and cancer.
several missense mutations in human cancers that disrupt the POT1C-TPP1 (show TPP1 Proteins) interaction, resulting in POT1 instability, were identified.
melanoma associated (show ZNF654 Proteins) POT1 germline variants seem to be rare.
Results indicate that lenti-shRNA-mediated POT1-KD significantly reduced POT1 mRNA and protein expression. POT1-KD immediately downregulated c-Myc (show MYC Proteins) expression, which led to the inhibition of cell proliferation, tumorigenesis, and HDACi response
A role of POT1 germline mutations in cancer predisposition beyond melanoma development
loss-of-function mutations in protection of telomeres 1 (POT1) co-segregated with Chronic lymphocytic leukemia.
the study identifies mutations in KRAS and POT1 as novel determinants of outcome after chemoimmunotherapy using chlorambucil and anti-CD20 (show MS4A1 Proteins) treatment.
Lung fibroblasts deficient in Sirt1 (show SIRT1 Proteins) or treated with a selective Sirt1 (show SIRT1 Proteins) inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Proteins) levels, whereas Sirt1 (show SIRT1 Proteins) overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Proteins) reduction and telomeric DNA damage.
Binding of POT1-TPP1 (show TPP1 Proteins) unfolds telomere secondary structure to assist loading of additional heterodimers.
We found that NEK6 (show NEK6 Proteins)-mediated phosphorylation of TPP1 (show TPP1 Proteins) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 Proteins). Furthermore, we found evidence that POT1 negatively regulates TPP1 (show TPP1 Proteins) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains
The tissue expression analysis indicated that the swine POT1 gene is differentially expressed in tissues including muscle, heart, liver, fat, kidney, lung, pancreas and spleen.
The telomere binding protein POT1a inhibits the production of reactive oxygen species, and rejuvenates aged hematopoietic stem cells.
proliferation of cancer cells lacking POT1 is enabled by the attenuation of the ATR kinase pathway.
demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (show TINF2 Proteins) phenocopy the POT1a,b knockout setting without showing additional phenotypes
The results of this study found telomere uncapping by Pot1a inactivation resulted in an Atm (show ATM Proteins)-dependent loss of cerebellar interneurons and granule neuron precursors in the mouse nervous system. The
shelterin protein TIN2 (show TINF2 Proteins) can protect chromosome ends as a TRF2 (show TERF2 Proteins)-tethered TIN2 (show TINF2 Proteins)/TPP1 (show TPP1 Proteins)/POT1 complex that lacks a physical connection to TRF1 (show TERF1 Proteins)
Simultaneous inactivation of Pot1a and p53 (show TP53 Proteins) resulted in endometrial intraepithelial carcinoma-like lesions in transgenic mice.
Telomere protection by TPP1 (show TPP1 Proteins)/POT1 requires tethering to TIN2 (show TINF2 Proteins).
POT1a degradation resulted in rapid and reversible activation of the ATR pathway in G1 and S/G2 (show STRN3 Proteins).
The ability of mPot1 to unfold the antiparallel tetraplex of the mouse telomeric DNA is required for telomerase-mediated telomere elongation.
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
POT1-like telomere end-binding protein
, protection of telomeres 1 homolog
, protection of telomeres protein 1
, POT1 protection of telomeres 1 homolog
, single-strand telomeric DNA-binding protein
, POT1 protection of telomeres 1 homolog (S. pombe)
, protection of telomeres 1
, protection of telomeres 1 homolog (S. pombe)
, protection of telomeres protein 1-like
, protection of telomeres 1A