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anti-Human RBX1 Antibodies:
anti-Mouse (Murine) RBX1 Antibodies:
anti-Rat (Rattus) RBX1 Antibodies:
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Human Polyclonal RBX1 Primary Antibody for WB - ABIN1944784
Ohta, Michel, Schottelius, Xiong: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. in Molecular cell 1999
Show all 2 Pubmed References
Human Polyclonal RBX1 Primary Antibody for ELISA - ABIN564293
Achiwa, Hasegawa, Udagawa: Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines. in Nutrition and cancer 2013
Cow (Bovine) Polyclonal RBX1 Primary Antibody for WB - ABIN2792171
Zheng, Schulman, Song, Miller, Jeffrey, Wang, Chu, Koepp, Elledge, Pagano, Conaway, Conaway, Harper, Pavletich: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. in Nature 2002
Show all 2 Pubmed References
The crystal structure of a pentameric CRL2 (show CRLF2 Antibodies)(VHL (show VHL Antibodies)) complex, composed of Cul2 (show CUL2 Antibodies), Rbx1, Elongin B (show TCEB2 Antibodies), Elongin C (show TCEB1 Antibodies), and pVHL (show VHL Antibodies) reveals how Rbx1 interacts with Cullin 2 (show CUL2 Antibodies).
Study demonstrated that ROC1 was overexpressed in esophageal squamous cell carcinomas, which was positive associated with poor prognosis of esophageal cancer patients.
p97 (show EIF4G2 Antibodies) negatively regulates NRF2 (show GABPA Antibodies) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA Antibodies) from the KEAP1 (show KEAP1 Antibodies)-CUL3 (show CUL3 Antibodies) E3 complex.
Regulation of substrate ubiquitination and polyubiquitination takes place through Rbx1 rotations.
High RBX1 expression was related to poor tumor differentiation, advanced TNM (show ODZ1 Antibodies) stage, and lymph node metastasis in non-small cell lung cancer.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
ROC1 (show RIT1 Antibodies) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 Antibodies)/DEPTOR (show DEPTOR Antibodies) pathway.
Nedd8 (show NEDD8 Antibodies)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 Antibodies)-Rbx1 as wild-type Nedd8 (show NEDD8 Antibodies).
RBX1 E3 ubiquitin protein expression responsible with multiple genetic mechanism in the development of head and neck cancer.
This work sheds new light on the roles of NEDD8 (show NEDD8 Antibodies) lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.
Downregulation of Rbx1 caused accumulation of Emi1.
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B Antibodies) accumulation during the early stage of embryonic development
The SCF (show KITLG Antibodies)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Antibodies).
The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Antibodies) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Antibodies)- and RBX-1-CUL-2 (show CUL2 Antibodies)-based complexes.
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF (show KITLG Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies).
Roc1b, Roc1a and Roc2 (show RIT2 Antibodies) proteins play nonredundant roles during development
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
E3 ubiquitin-protein ligase RBX1
, RING box protein 1
, RING finger protein 75
, RING-box protein 1
, ZYP protein
, regulator of cullins 1
, ring-box protein 1
, ring-box 1
, hyperosmotic protein 21
, CG16982 gene product from transcript CG16982-RC
, Regulator of cullins 1a
, regulator of cullins 1a