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anti-Human FBP1 Antibodies:
anti-Mouse (Murine) FBP1 Antibodies:
anti-Rat (Rattus) FBP1 Antibodies:
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Human Polyclonal FBP1 Primary Antibody for IHC, IHC (p) - ABIN4310717
Li, Qiu, Lee, Walton, Ochocki, Mathew, Mancuso, Gade, Keith, Nissim, Simon: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. in Nature 2014
Cow (Bovine) Polyclonal FBP1 Primary Antibody for IHC, WB - ABIN2776794
Yáñez, Bertinat, Spichiger, Carcamo, de Los Angeles García, Concha, Nualart, Slebe: Novel expression of liver FBPase in Langerhans islets of human and rat pancreas. in Journal of cellular physiology 2005
Show all 2 Pubmed References
Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.
Studied association of fructose 1,6-bisphosphatase 1 (FBP1) expression with fluorine 18 ((18)F) fluorodeoxyglucose (FDG (show SMUG1 Antibodies)) accumulation in patients with hepatocellular carcinoma. Found that in patients with HCC (show FAM126A Antibodies), both 18F FDG (show SMUG1 Antibodies) accumulation and tumor grade (from differentiated to undifferentiated) were inversely correlated with the expression of FBP1.
These findings indicate that FBP1 appears to be a tumor suppressor in hepatocellular carcinoma (HCC (show FAM126A Antibodies)). Strategies to restore the levels and activities of FBP1 might be developed to treat patients with HCC (show FAM126A Antibodies).
The redistribution of FBP3 (show FUBP3 Antibodies) in subcellular compartments was observed after Enterovirus 71 (EV71) infection, and the decreased expression of FBP3 (show FUBP3 Antibodies) in host neuronal cells markedly inhibited viral replication. The results reveal various host proteins that potentially interact with the EV71 5'UTR (show UTS2R Antibodies) in neuronal cells, and study found that FBP3 (show FUBP3 Antibodies) could serve as a positive regulator in host cells.
FBP1 underexpression is associated with Tumor Progression in Hepatocellular Carcinoma.
fructose-1,6-bisphosphatase 1 facilitated co-action between Bcl-2 (show BCL2 Antibodies) and Beclin 1 (show BECN1 Antibodies), which may be important in the mechanism of fructose-1,6-bisphosphatase 1-mediated mitophagy inhibition. In summary, loss of mitophagy by fructose-1,6-bisphosphatase 1-mediated repression promotes apoptosis in breast cancer
Downregulation of FBP1 promotes gastric cancer metastasis by facilitating EMT (show ITK Antibodies) and acts as a potential prognostic factor and therapeutic target in gastric cancer.
we show that EV71 viral proteinase 2A is capable of cleaving far upstream element-binding protein 1 (show FUBP1 Antibodies) (FBP1), a positive internal ribosome entry sitet rans-acting factor that directly binds to the EV71 5' UTR (show UTS2R Antibodies) linker region to promote viral IRES-driven translation
Cox (show COX8A Antibodies) multivariate regression analysis demonstrated that DUOX1 (show DUOX1 Antibodies), GLS2 (show GLS2 Antibodies), FBP1 and age were independent risk factors for the prognosis of HCC (show FAM126A Antibodies) patients after surgery
Elevated FBP1 is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
FBPase plays an important role in regulating glucose sensing and insulin (show INS Antibodies) secretion of beta-cells and serves a promising target for diabetes treatment.
Data show that NF-kappaB (show NFKB1 Antibodies) functions downstream of Ras to promote epigenetic downregulation of FBP1 (show FBP2 Antibodies).
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP (show TMPRSS5 Antibodies)/fructose 2,6-bisphosphate synergism.
The AMP (show TMPRSS5 Antibodies)/Mg(2 (show MCOLN1 Antibodies)+) and AMP (show TMPRSS5 Antibodies)/Zn(2+) complexes of Asp (show ASIP Antibodies)(10) FBPase are in intermediate quaternary conformations.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2 (show MCOLN1 Antibodies)+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Ca2 (show CA2 Antibodies)+ appears to be a strong inhibitor of muscle FBPase (fructose 1,6-diphosphatase).
May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression.
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
, FBPase 1
, fructose-bisphosphatase 1
, growth-inhibiting protein 17
, D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
, FBPase brain isoform
, FBPase liver
, fructose-1,6-bisphosphatase 1
, fructose-1,6-bisphosphatase isozyme 3
, fructose 1,6-bisphosphatase
, FUSE-binding protein 3
, far upstream element-binding protein 3
, Fructose-16- biphosphatase
, fructose-1,6- biphosphatase 1
, fructose-1,6-bisphosphatase 1, like
, fructose-bisphosphatase 1 S homeolog