Browse our Ankyrin Repeat Domain 1 (Cardiac Muscle) Proteins (ANKRD1)

Human Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) interaction partners

1. review of CARP (show CA8 Proteins), including its discovery, structure, and the role it plays in cardiac development and heart diseases [review]

2. These data suggest that hepatitis C virus coopts ANKRD1 for its own propagation and up-regulation of ANKRD1 may contribute to hepatitis C virus-mediated liver pathogenesis.

3. To the Ankrd1, it is not responsive to the cardiotoxic drug Doxorubicin, suggesting that different mechanisms govern their expression in cardiac cells.

4. The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure.

5. Report structure activity relationships for ANKRD1.

6. ANKRD1 has a significant role in the regulation of apoptosis in human ovarian cancer cells

7. Augmented CARP (show CA8 Proteins) expression may be a common molecular event in failing hearts regardless of cardiomyopathic aetiology.

8. Report impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue.

9. the 26S proteasome (show Psmd4 Proteins) is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min).

10. Ankrd1 and desmin (show DES Proteins) may play important roles in airway smooth muscle cell homeostasis.

Mouse (Murine) Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) interaction partners

1. The results suggest that CARP can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 (show BCL2 Proteins) gene expression.

2. Overexpression of Ankrd1 exacerbates pathological cardiac remodeling through the enhancement of cytosolic translocation of CARP and up-regulation of calcineurin.

3. ANKRD1 modulates inflammatory responses in myoblasts through feedback inhibition of NF-kappaB (show NFKB1 Proteins) signaling activity.

4. ANKRD1 is important for the proper interaction of fibroblasts with a compliant collagenous matrix both in vitro and in vivo

5. Overexpression of Ankrd1 exacerbates pathological cardiac dysfunction through enhancement of cardiomyocyte apoptosis mediated by the up-regulation of p53 (show TP53 Proteins).

6. CARP, Ankrd2 (show ANKRD2 Proteins), and DARP (show Ankrd23 Proteins) are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload.

7. ANKRD1, in association with factors such as nucleolin (show NCL Proteins), represses MMP13 (show MMP13 Proteins) transcription. Ankrd1 deletion additionally relieved MMP10 (show MMP10 Proteins) transcriptional repression

8. CARP attenuates cardiac hypertrophy, in which the ERK (show EPHB2 Proteins) and TGF-beta (show TGFB1 Proteins) pathways may be involved. Our findings highlight the significance of CARP as an anti-hypertrophic factor in therapy of cardiac hypertrophy

9. CARP is expressed during adulthood in response to neurological stimuli, such as kainic acid-induced seizures.

10. Data show that CARP specific expressed in mouse heart and mainly localized in the nucleus in rat cardiac primary cells.

Pig (Porcine) Ankyrin Repeat Domain 1 (Cardiac Muscle) (ANKRD1) interaction partners

1. Expression analysis in porcine satellite cells showed that CARP and ANKRD2 (show ANKRD2 Proteins) were induced in differentiated porcine satellite cells, suggesting a role of them in myogenic differentiation.

2. endogenous ANKRD1 and calsequestrin are co-enriched in piglet cardiac Purkinje cells

3. CAPZB (show CAPZB Proteins), ANKRD1, and CTBP2 (show CTBP2 Proteins) are promoted as candidate genes for meat quality that provide a link between signal pathways.