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Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII.
Ctr9 (show CTR9 Antibodies), a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha (show ESR1 Antibodies)(+) breast tumorigenesis
Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment.
CTR9 (show CTR9 Antibodies) is a PAF1 (show PEX2 Antibodies) complex gene whose germline mutations predispose to Wilms tumour
CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
MLL (show MLL Antibodies) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (show PEX2 Antibodies) and CTR9 (show CTR9 Antibodies). PAFc augments MLL (show MLL Antibodies) and MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) mediated transcriptional activation of Hoxa9 (show HOXA9 Antibodies) and their interaction is essential for leukemogenesis.
CTR9 (show CTR9 Antibodies) participates in the transcription of IL-6 (show IL6 Antibodies)-responsive genes through the regulation of DNA association of STAT3 (show STAT3 Antibodies) and modification of histone methylation
CTR9, parafibromin (CDC73\; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Ctr9, Paf1/RNA polymerase II complex component, homolog
, RNA polymerase-associated protein CTR9 homolog
, SH2 domain binding protein 1 (tetratricopeptide repeat containing)
, SH2 domain-binding protein 1
, TPR-containing, SH2-binding phosphoprotein