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anti-Human CTR9 Antibodies:
anti-Mouse (Murine) CTR9 Antibodies:
anti-Rat (Rattus) CTR9 Antibodies:
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A novel CTR9 germline variant, located in a consensus splice acceptor site, was found to segregate with Wilms tumor in the family.
Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha (show ESR1 Antibodies)-target gene expression by regulating global chromatin occupancies of ERalpha (show ESR1 Antibodies) and RNAPII (show Pol II Antibodies).
Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha (show ESR1 Antibodies)(+) breast tumorigenesis
Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment.
CTR9 is a PAF1 (show PEX2 Antibodies) complex gene whose germline mutations predispose to Wilms tumour
CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.
MLL (show MLL Antibodies) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (show PEX2 Antibodies) and CTR9. PAFc augments MLL (show MLL Antibodies) and MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) mediated transcriptional activation of Hoxa9 (show HOXA9 Antibodies) and their interaction is essential for leukemogenesis.
CTR9 participates in the transcription of IL-6 (show IL6 Antibodies)-responsive genes through the regulation of DNA association of STAT3 (show STAT3 Antibodies) and modification of histone methylation
our data suggest that Setd5 is required for maintaining PGC (show PGC Antibodies)-associated genes and Setd5-associated protein complexes containing Tbl1xr1 (show TBL1XR1 Antibodies) and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs
these data propose a novel feed-forward loop of IL-17 (show IL17A Antibodies) transcriptional regulatory circuit, via IL-6 (show IL6 Antibodies)-mediated repression of CTR9 which is a transcriptional repressor of IL-17 (show IL17A Antibodies).
CTR9, parafibromin (CDC73\; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Ctr9, Paf1/RNA polymerase II complex component, homolog
, RNA polymerase-associated protein CTR9 homolog
, SH2 domain binding protein 1 (tetratricopeptide repeat containing)
, SH2 domain-binding protein 1
, TPR-containing, SH2-binding phosphoprotein
, TPR-containing, SH2-binding phosphoprotein of 150 kDa
, tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa
, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
, SH2 domain binding protein 1