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ETBR function contributes to diminished endothelium-dependent dilation in previously preeclamptic women.
ETA and ETB receptors are present in human haemorrhoids with ETB receptors predominating
An IL2 (show IL2 Proteins)-targeted antibody failed to detect transfected ETB in HEK293 cultures. In contrast, the NT-targeted antibody accurately detected transfected ETB in HEK293 cultures by labeling a 37-kDa band.
In control arteries, ETAR (show EDNRA Proteins) was expressed by vascular smooth muscle cells in the media whereas ETBR was hardly detected. In giant cell arteritis, both ETAR (show EDNRA Proteins) and ETBR receptors were expressed by alphaSMA (show ACTA2 Proteins)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.
This study concluded that ETB receptors mediate vasodilation in young women, but this effect is lost after menopause.
Our results suggest that EDNRB rs5351 single nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin.
No rare EDNRB variants were identified among 57 patients with Hirschsprung disease.
Taking into account that the cohort we screened was deprived of patients previously found mutated in MITF (show MITF Proteins) (about 15%) and SOX10 (show SOX10 Proteins) (another 15%), our 8% mutation rate indicates that EDNRB heterozygous mutations represent about 5%-6% of all WS2 (show MITF Proteins), making it the third gene of this subtype.
Data suggest that TNFalpha (tumor necrosis factor-alpha (show TNF Proteins)) induces proliferation of airway smooth muscle cells via ET1 (endothelin-1 (show EDN1 Proteins)), GM-CSF (granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)), and IL6 (interleukin 6 (show IL6 Proteins)) signaling; ET1 (show EDN1 Proteins) induces cell proliferation via ETAR (endothelin receptor type A (show EDNRA Proteins)); ETBR (endothelin receptor type B) is up-regulated by TNFalpha (show TNF Proteins) and appears to mediate ET1 (show EDN1 Proteins) effects on cell proliferation.
genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3 (show EDN3 Proteins)) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer.
PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.
ET(A (show EDNRA Proteins))/ET(B) blockade decreased pulmonary vascular resistance but only during exercise.
endothelial endothelin ET(B) receptors induce NO and EDHF mediated vasodilatation in porcine coronary arteries; in organ culture, endothelial endothelin ET(B) receptors are down-regulated
PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
extracellular ET-1 (show EDN1 Proteins) regulates the abundance of ET-1 (show EDN1 Proteins) mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK (show MAPK1 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways
Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR (show EDNRA Proteins) antagonists might be beneficial for treatment of laminitis in horses.
both ETA and ETB receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins
Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.
ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.
ETB receptor signaling is involved in skin sclerosis and in collagen synthesis by dermal fibroblasts
mmLDL increased the serum concentrations and expression of ICAM-1 (show ICAM1 Proteins) and VCAM-1 (show VCAM1 Proteins) by activating the ERK1/2 pathway, resulting in the expression of ETB receptors and the enhancement of contractile function in vascular smooth muscle.
ETB receptors in vascular smooth muscle make a small but significant contribution to ETB-dependent regulation of BP. These ETB receptors have no effect on vascular contraction or neointimal remodeling.
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 (show EDN1 Proteins) via upregulation of the ETB receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss.
we show that ET-1 (show EDN1 Proteins) acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination.
EDNRB plays a key role in hypoxia tolerance
The cardiac expression of prepro-endothelin-1 (show EDN1 Proteins) mRNA, endothelin-converting enzyme-1 (show ECEL1 Proteins) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
results indicate that the Notch1 (show NOTCH1 Proteins)-STAT3 (show STAT3 Proteins)-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury
Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelin B receptor
, endothelin receptor non-selective type
, endothelin receptor subtype B
, endothelin-B receptor
, endothelin ETB receptor
, endothelin receptor B
, endothelin receptor type B