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anti-Human HMGB2 Antibodies:
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Human Monoclonal HMGB2 Primary Antibody for IHC (p), ELISA - ABIN516538
Kwon, Kim, Park, Hong, Park, Hong, Park, Choi, Do, Joh, Kim, Choi: Overexpression of high-mobility group box 2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Knockdown of HMGB2 expression by stable transfected shRNA significantly decreased the growth and glycolysis of breast cancer cells both in vitro and in mouse models.
HMBG2 overexpression promotes ischemia/reperfusion-induced cell apoptosis through activating the JNK1/2-NF-kappaBp65 signaling in AC16 cardiomyocytes.
Authors demonstrate that HMGB2 transcription is repressed by p21 during radiation-induced senescence through the ATM-p53-p21 DNA damage signaling cascade. The loss of p21 abolished the downregulation of HMGB2 caused by ionizing radiation, and the conditional induction of p21 was sufficient to repress the transcription of HMGB2.
Multiple functions of HMGB proteins reveal the complex roles of these proteins as innate and endogenous regulators of inflammation in joints and their cooperative roles in cartilage hypertrophy as well as in the maintenance of joint tissue homeostasis.
identified the oncogene HMGB2 as a downstream target of miR-130a by using luciferase and western blot assays. Knockdown of HMGB2 mimicked the effect of miR-130a in glioma cells.
downregulation of HMGB1 and/or HMGB2 in undifferentiated human embryonic stem cells does not affect the stemness of cells.
Serum HMGB2 levels were associated with in-stent restenosis in patients.
results establish HMGB2 as a novel master regulator that orchestrates senescence-associated secretory phenotype.
Data indicate the function of high mobility group box 2 (HMGB2) in glycolytic control in pancreatic cancer.
data demonstrate a reciprocal relationship between Hmgb2 and Ctcf in controlling aspects of chromatin structure and gene expression.
Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1.
Data show that odulation of RNA helicase DDX18 directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.
siRNA-mediated silencing of HMGB2 increased the sensitivity of the head and neck squamous cell carcinoma cell lines to cisplatin and 5-fluorouracil.
the combination of a HMGB1+ and HMGB2- expression potentially predicts a poor prognosis in patients with pancreatic ductal adenocarcinoma
This study found that single nucleotide polymorphisms of HMGB1 may serve as potential biomarkers for predicting the efficacy of platinum-based chemotherapy.
The present data suggest that HMGB2 expression is a significant prognostic factor for glioblastoma and might play an important role in cell invasion.
HMGB2 is necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and p53-mediated downregulation is a critical mechanism of modulating HMGB2 expression.
Transient local HMGB2-DNA contacts dominate the DNA-bending mechanism used by HMGB proteins to increase DNA flexibility.
Crohn's disease in the colon and ulcerative colitis can be differentially diagnosed using anti-HMGB/HMGB2 antibodies combined with anti-Saccharomyces cerevisiae antibodies.
The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.
HMGB2 expression is strongly associated with transition from the quiescent to the proliferative state of neural stem cells, supporting the possibility that HMGB2 is involved in the regulation of adult neurogenesis and can be used as a novel marker to identify neural stem cells primed for activation in the adult hippocampus.
these results highlight the previously undiscovered and crucial role of the HMGB2-IGF2BP2 axis in myogenesis and muscle regeneration.
HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation.
HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation.
Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex.
HMGB2 (but not HMGB1) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth
Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs.
High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion.
In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence.
Increased HMGB2 expression is associated with squamous cell carcinoma of skin.
an interaction between HMGB2 and the Wnt/beta-catenin pathway regulates the maintenance of the superficial zone
high-mobility group box (HMGB) proteins function as universal sentinels for nucleic acids
results show that, in contrast to other Arabidopsis HMGB proteins such as HMGB1 and HMGB5, the HMGB2/3 and HMGB4 proteins occur preferentially in the cell nucleus, but to various extents also in the cytoplasm
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
, high mobility group protein 2
, high mobility group protein B2
, high-mobility group (nonhistone chromosomal) protein 2
, high-mobility group box 2
, non-histone chromosomal protein
, non-histone protein HMG2
, high mobility group box 2b
, high-mobility group box 2, like