Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR (show MLXIP Proteins)-433 expression. Its knockdown showed similar tumor-suppressive roles as miR (show MLXIP Proteins)-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR (show MLXIP Proteins)-433 overexpression in regards to proliferation, invasion and of cervical cancer cells.
Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.
miR (show MLXIP Proteins)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
Reduction of TUG1 level suppressed cell growth and metastasis by regulating AEG1 expression mediated by targeting miR (show MLXIP Proteins)-129-5p.
miR96 may impede the epithelial to mesenchymal transition process by downregulating AEG1 in glioblastoma cancer cells.
The findings demonstrated that miR (show MLXIP Proteins)-379 may play tumor-suppressing roles in glioma through downregulation of MTDH and regulation of the PTEN/AKT (show AKT1 Proteins) signaling pathway.
High AEG1 expression was associated with Oral Squamous Cell Carcinomas.
miR675 expression was downregulated in melanoma tissues and cell lines. Functional assays demonstrated that the upregulation of miR675 impaired cell proliferation and invasion in melanoma. Bioinformatics analysis, luciferase reporter assay, reverse transcriptionquantitative polymerase chain reaction and western blot analysis demonstrated that metadherin (MTDH) was a direct target of miR675 in melanoma.
Our findings provided evidence that AEG-1 contributed to the production of inflammatory cytokines, migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes, and underscored the importance of AEG-1 in the inflammation process of rheumatoid arthritis
High MTDH expression is associated with gastric cancer metastasis.
Knockdown of MTDH expression also upregulated PTEN and suppressed pAKT (show AKT1 Proteins) protein expression in Caki2 cells. In conclusion, the present study is the first, to the best of our knowledge, to provide evidence suggesting that miRNA30a5p suppresses tumor human renal cancer cell proliferation via the MTDH/PTEN/AKT (show AKT1 Proteins) pathway
These results suggested that miR216b acted as a tumor suppressor in glioma by directly targeting MTDH and that the miR216b/MTDH axis may be an effective therapeutic target for the treatment of patients with this disease
AEG-1 functions as a selective endoplasmic reticulum mRNA-binding protein.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein