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Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
miR (show MLXIP Proteins)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).
Findings clearly demonstrate that miR (show MLXIP Proteins)-320a suppresses breast cancer metastasis by directly inhibiting MTDH expression. The present study provides a new insight into anti-oncogenic roles of miR (show MLXIP Proteins)-320a.
Results show that miR (show MLXIP Proteins)-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells through targeting AEG-1.
AEG-1 knockdown inhibits migration and invasion, as well as radiation-enhanced invasion both in vitro and in vivo I colonic cancer cells.
Study shows that expression of AEG-1 was significantly higher in macrophages and associated with elevated expression levels of MMP-9 (show MMP9 Proteins) in hypopharyngeal cancer. These results demonstrate that macrophage AEG-1 promotes tumor invasion through up-regulation of MMP-9 (show MMP9 Proteins) in both macrophages and cancer cells.
Gene expression data and in silico database analysis showed that the metadherin gene (MTDH) was a direct target of both miR (show MLXIP Proteins)-145-5p and miR (show MLXIP Proteins)-145-3p regulation and high expression of MTDH predicted poorer survival of lung squamous cell carcinoma patients.
Results demonstrated that AEG-1 significantly enhanced invasion capabilities of OVCAR3 ovarian cancer cells and suggested that HIF-1alpha (show HIF1A Proteins) binds to AEG-1 promoter to upregulate its expression, which was correlated with metastasis in ovarian cancer.
The present work aims to investigate the relationship between the expression of AEG-1(astrocyte elevated gene-1), b-FGF(basic-fibroblast growth factor (show FGF2 Proteins)), beta-catenin (show CTNNB1 Proteins), Ki-67 (show MKI67 Proteins), TNF-alpha (tumor necrosis factor (show TNF Proteins)-alfa) other prognostic parameters in DC (Ductal Carcinomas) and ductal intraepithelial neoplasm. We found a relationship between these factors.
Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2 (show SOX2 Proteins). AEG-1 facilitated beta-catenin (show CTNNB1 Proteins) translocation into the nucleus by forming a complex with LEF1 (show LEF1 Proteins) and beta-catenin (show CTNNB1 Proteins), subsequently activating Wnt (show WNT2 Proteins) signaling downstream genes.
High MTDH expression is associated with glioblastomas.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein