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Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR (show MLXIP Proteins)-433 expression. Its knockdown showed similar tumor-suppressive roles as miR (show MLXIP Proteins)-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR (show MLXIP Proteins)-433 overexpression in regards to proliferation, invasion and of cervical cancer cells.
Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.
miR (show MLXIP Proteins)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
High MTDH expression is associated with colorectal cancer.
miR (show MLXIP Proteins)-655 directly targets and downregulates MTDH mRNA expression in oral squamous cell carcinoma cells.
Metadherin (MTDH) was validated as a direct target gene of miR874 in retinoblastoma cells.
AEG-1 as a target gene of miR (show MLXIP Proteins)-216b action.
AEG-1 participates in the effects of miR (show MLXIP Proteins)-625-3p on thyroid cancer cells.
Findings provide the first evidence that the aberrant expression of miR (show MLXIP Proteins)-136 may be implicated into carcinogenesis and cancer progression of OS. Functionally, miR (show MLXIP Proteins)-136 may inhibit the proliferation, migration and invasion of OS cells via negatively regulating its target gene MTDH.
AEG-1 was found to be significantly associated with hypoxia in ovarian cancer by regulating the HIF-1alpha (show HIF1A Proteins)/NF-kappaB (show NFKB1 Proteins)/VEGF (show VEGFA Proteins) pathway.
Reduction of TUG1 level suppressed cell growth and metastasis by regulating AEG1 expression mediated by targeting miR (show MLXIP Proteins)-129-5p.
miR96 may impede the epithelial to mesenchymal transition process by downregulating AEG1 in glioblastoma cancer cells.
The findings demonstrated that miR (show MLXIP Proteins)-379 may play tumor-suppressing roles in glioma through downregulation of MTDH and regulation of the PTEN/AKT (show AKT1 Proteins) signaling pathway.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein