Browse our anti-NLRP3 (NLRP3) Antibodies

Full name:: anti-NLR Family, Pyrin Domain Containing 3 Antibodies (NLRP3)

On www.antibodies-online.com are 226 NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies from 28 different suppliers available. Additionally we are shipping NLRP3 Kits (11) and NLRP3 Proteins (4) and many more products for this protein. A total of 257 NLRP3 products are currently listed.

Synonyms:: AGTAVPRL, AII, AII/AVP, AVP, C1orf7, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, NALP3, Pypaf1

list all antibodies	Gene Name	GeneID	UniProt
	NLRP3	114548	Q96P20
	NLRP3	216799	Q8R4B8
	NLRP3	287362
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Top referenced anti-NLRP3 Antibodies

Human Polyclonal NLRP3 Primary Antibody for ICC, IF - ABIN4340123 : Wang, Pan, Zhang, Wang, Kong: Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. in PLoS ONE 2012 (PubMed)
Show all 35 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for ELISA, ICC - ABIN4340113 : Chamaillard, Girardin, Viala, Philpott: Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. in Cellular microbiology 2003 (PubMed)
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Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361 : Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015 (PubMed)
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Human Monoclonal NLRP3 Primary Antibody for CyTOF, FACS - ABIN4898963 : Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016 (PubMed)
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Human Monoclonal NLRP3 Primary Antibody for IHC, IP - ABIN1169100 : Zhou, Tardivel, Thorens, Choi, Tschopp: Thioredoxin-interacting protein links oxidative stress to inflammasome activation. in Nature immunology 2010 (PubMed)
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Human Polyclonal NLRP3 Primary Antibody for IHC, IHC (p) - ABIN4340115 : Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009 (PubMed)
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Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117 : Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009 (PubMed)
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Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577 : Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015 (PubMed)
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Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504 : Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015 (PubMed)
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Human Polyclonal NLRP3 Primary Antibody for WB - ABIN3043571 : Xue, Wang, Du, Zhu: Maternal obesity induces gut inflammation and impairs gut epithelial barrier function in nonobese diabetic mice. in The Journal of nutritional biochemistry 2014 (PubMed)
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More Antibodies against NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

uHSP72 may be considered as a novel potential diagnostic biomarker for the early detection of Diabetic nephropathy (DN). Moreover, these data support the pivotal role of NLRP3 in the development and progression of DN
TIFA (show IL22 Antibodies) is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2
To investigate the correlation between P2X7R (show P2RX7 Antibodies), NLRP3 and cell growth, NLRP3 was silenced in THP-1 (show GLI2 Antibodies) cells, a leukemic cell line that natively expresses both NLRP3 and P2X7R (show P2RX7 Antibodies). NLRP3 silencing enhanced P2X7R (show P2RX7 Antibodies) expression and promoted growth. On the contrary, NLRP3 overexpression caused accelerated apoptosis.
High levels of NLRP3 is associated with oral squamous cell carcinoma.
both RAGE (show AGER Antibodies) and mitochondrial damage primed NLRP3 and pro-IL-1beta (show IL1B Antibodies) activation as upstream signals of NF-kappaB (show NFKB1 Antibodies) activity, whereas mitochondrial damage was critical for the assembly of inflammasome components. These results revealed that accumulation of AGEs in NP tissue may initiate inflammation-related degeneration of the intervertebral disc via activation of the NLRP3 inflammasome.
intracellular TXNIP (show TXNIP Antibodies) protein is a critical regulator of activation of the fructose-induced NLRP3 inflammasome
While the detection of NLRP3 gene mutations may be viewed as confirmatory, CAPS (show CAPS Antibodies) is still predominantly a clinical diagnosis; therefore, recently published diagnostic criteria do not require the demonstration of a mutation.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (show MEFV Antibodies) domain 1 and 3 (NLRP1 (show NLRP1 Antibodies) and NLRP3) inflammasomes and induced the release of IL-1beta (show IL1B Antibodies) and pyroptosis via a caspase-1 (show CASP1 Antibodies)-related mechanism in human periodontal ligament cells (HPDLCs).
A total of 163 patients and 201 health controls were enrolled in this study and polymorphisms of NLPR1, NLRP3, and P2X7R genes were detected by PCR..Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population
Similar carrier rate of the NLRP3-Q703K allele among patients with manifestations of autoinflammatory disease and an ethnically matched control group suggest that this variant, does not determine the clinical phenotype.

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

After irradiation, the pyroptosis caused by the activation of NLRP3 inflammatory body occurred in the lung tissue of mice.
These data provide evidence that the inflammasome components ASC (show STS Antibodies), NLRP3 and AIM2 (show AIM2 Antibodies) play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.
MPTP (show PTPN2 Antibodies) was toxic to mouse thymus via a mechanism involving the NF-kappaB (show NFKB1 Antibodies) and NLRP3 inflammasome pathway
Studied effects of melatonin in mouse model of sepsis; found the NF-kappaB (show NFKB1 Antibodies)/ NLRP3 signal pathway is target for melatonin.
NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein (NLRP3)-/- mice exhibited less severe non-alcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) than WT mice, whereas thioredoxin-interacting protein (TXNIP (show TXNIP Antibodies)) deficiency enhanced NLRP3 inflammasome.
NLRP3 gene deletion attenuates Ang II (show AGT Antibodies)-induced NLRP3 inflammasome activation, phenotypic transformation from a contractile phenotype to a synthetic phenotype and proliferation in primary mice Vascular Smooth Muscle Cells.
These results indicate that the NLRP3 inflammasome inhibitor, MCC950, attenuates brain injury and inflammation after ICH (show ACE Antibodies). Hence, NLRP3 inflammasome inhibition is a potential therapy for ICH (show ACE Antibodies) that warrants further investigation.
Reperfusion therapy with recombinant human relaxin-2 (show RLN1 Antibodies) (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS (show NOS3 Antibodies)-dependent mechanism.
Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS (show ROS1 Antibodies)-TXNIP (show TXNIP Antibodies)-NLRP3 axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D.

NLRP3 Antigen Profile

Antigen Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Alternative names and synonyms associated with NLRP3

NLR family pyrin domain containing-like (NLRPL) antibody
NLR family pyrin domain containing 3 (NLRP3) antibody
NLR family, pyrin domain containing 3 L homeolog (nlrp3.L) antibody
NLR family, pyrin domain containing 3 (Nlrp3) antibody

AGTAVPRL antibody
AII antibody
AII/AVP antibody
AVP antibody
C1orf7 antibody
Cias1 antibody
CLR1.1 antibody
FCAS antibody
FCU antibody
Mmig1 antibody
MWS antibody
NALP3 antibody
Pypaf1 antibody

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID	SPECIES
423021	Gallus gallus
469743	Pan troglodytes
490576	Canis lupus familiaris
100351623	Oryctolagus cuniculus
100381165	Xenopus laevis
100392399	Callithrix jacchus
114548	Homo sapiens
216799	Mus musculus
538639	Bos taurus
287362	Rattus norvegicus
701278	Macaca mulatta

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Show all anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies with Pubmed References

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

Antigen Summary

Alternative names and synonyms associated with NLRP3

Protein level used designations for NLRP3