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Mouse (Murine) phosphodiesterase 4D, cAMP-Specific (PDE4D) interaction partners

1. These results indicate that Phosphodiesterase-4D overexpression may be involved in the development of surgery-induced cognitive dysfunction in mice.

2. The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D

3. In vivo knockdown of (show FN1 Proteins) PDE4D5 inhibited inflammation at athero-prone sites (show TWIST1 Proteins)

4. Results indicate that the cyclic AMP (show TMPRSS5 Proteins) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (show TWIST1 Proteins)) activity adrenal cortex-derived Y-1 cell line.

5. The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (show CREB1 Proteins) signaling exerted by a kinase-independent PI3Kgamma (show PIK3CG Proteins)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.

6. SIK1 serves as a part of a self-regulatory circuit to modulate insulin (show INS Proteins) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.

7. Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.

8. the loss of function of either DISC1 (show DISC1 Proteins) or ATF4 (show ATF4 Proteins) increases PDE4D9 transcription, and the association of DISC1 (show DISC1 Proteins) with the PDE4D9 locus requires ATF4 (show ATF4 Proteins)

9. these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.

10. Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D.

Human phosphodiesterase 4D, cAMP-Specific (PDE4D) interaction partners

1. Results provide new information concerning the mechanism whereby the mutations identified in the ACRDYS2 dysregulate PDE4D activity, and give insights into rare diseases involving the cAMP signaling pathway.

2. This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route

3. PDE4D isoform composition is altered in localized prostate cancer and it can be used both as a diagnostic as well as a prognostic biomarker.

4. Genetic analysis identified the identical, novel heterozygous missense mutation of the PDE4D gene c.569C>T (p.Ser190Phe) in two patients in same family. This case illustrates the significant phenotypic variability of acrodysostosis even within one family with identical mutations.

5. Screening of PRKAR1A (show PRKAR1A Proteins) and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism

6. p53 (show TP53 Proteins) induced the transcription of miR (show MLXIP Proteins)-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes.

7. High PDE4D expression is associated with melanoma.

8. cells on fibronectin (show FN1 Proteins) suppressed cAMP via enhanced phosphodiesterase (PDE (show ALDH7A1 Proteins)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5

9. we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population.

10. RACK1 (show GNB2L1 Proteins) and beta-arrestin2 (show ARRB2 Proteins) inhibit the dimerization of PDE4D5.

Cow (Bovine) phosphodiesterase 4D, cAMP-Specific (PDE4D) interaction partners

1. demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland