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Mouse (Murine) PLAU ELISA Kit for Sandwich ELISA - ABIN2010778
Siefert, Chabasse, Mukhopadhyay, Hoofnagle, Strickland, Sarkar, Antalis: Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice. in Journal of thrombosis and haemostasis : JTH 2014
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Human PLAU ELISA Kit for Sandwich ELISA - ABIN414931
Russo, Pietsch: Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD). in Biomarker insights 2013
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Human PLAU ELISA Kit for Sandwich ELISA - ABIN411365
Kim, Lee, Choi, Yoo, Yang: Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13. in Rheumatology international 2012
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Human PLAU ELISA Kit for Sandwich ELISA - ABIN612792
Wyrębska, Gach, Szemraj, Szewczyk, Hrabec, Koszuk, Janecki, Janecka: Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6) - a new compound with α-methylene-γ-lactone motif - on two breast cancer cell lines. in Chemical biology & drug design 2011
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Human PLAU ELISA Kit for Sandwich ELISA - ABIN2685206
Kiian, Tkachuk, Haller, Dumler: Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway. in Thrombosis and haemostasis 2003
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Mouse (Murine) PLAU ELISA Kit for Sandwich ELISA - ABIN415604
Kim, Hong, Eom, Lee, Park: Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. in Breast cancer research and treatment 2011
Human PLAU ELISA Kit for Sandwich ELISA - ABIN365814
Jin, Tan, Zhao, Sun, Zhu, Sun, Hao, Xing, Liu, Qu, Huang, Yang: Ultrasound-triggered thrombolysis using urokinase-loaded nanogels. in International journal of pharmaceutics 2012
Human PLAU ELISA Kit for Sandwich ELISA - ABIN2010724
Khan, Gupta, Kumar, Sharma, Kumar, Sharma: Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression. in Clinical & experimental metastasis 2014
Human PLAU ELISA Kit for Sandwich ELISA - ABIN1117732
Chen, Zou, Yang, Wang, Pan: Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo. in International journal of oncology 2014
OB-Rb (show LEPR ELISA Kits), RhoA (show RHOA ELISA Kits)/ROCK, PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits), JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) pathways and NF-kB activation are involved in leptin (show LEP ELISA Kits)-induced upA (show PRAP1 ELISA Kits) expression.
Results provide evidence that uPA (show PRAP1 ELISA Kits) and IGF1R (show IGF1R ELISA Kits) directly interact with uPAR (show PLAUR ELISA Kits) enhancing malignant potential of triple-negative breast cancer.
suggest that the low endogenous levels of uPA (show PRAP1 ELISA Kits) in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner
an intricate link between caveolin-1 (show CAV1 ELISA Kits) and Src kinase (show CSK ELISA Kits)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC ELISA Kits) expression through p53 (show TP53 ELISA Kits) and uPA (show PRAP1 ELISA Kits) system-mediated cross-talk, is reported.
results show that the uPA (show PRAP1 ELISA Kits)/uPAR (show PLAUR ELISA Kits)/LRP1 (show LRP1 ELISA Kits) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury
The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (show MMP9 ELISA Kits) activity and uPA (show PRAP1 ELISA Kits) expression through decreasing of IKK-beta (show IKBKB ELISA Kits)-mediated NF-kappaB (show NFKB1 ELISA Kits) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.
These studies identify uPA (show PRAP1 ELISA Kits)-dependent de-repression of vegfr1 (show FLT1 ELISA Kits) and vegfr2 (show KDR ELISA Kits) gene transcription through binding to HHEX/PRH (show HHEX ELISA Kits) as a novel mechanism by which uPA (show PRAP1 ELISA Kits) mediates the pro-angiogenic effects of VEGF (show VEGFA ELISA Kits) and identifies a potential new target for control of pathologic angiogenesis.
We concluded that overexpression of MMP-3 (show MMP3 ELISA Kits) and uPA (show PRAP1 ELISA Kits), altogether with diminished expression of PAI-1 (show SERPINE1 ELISA Kits) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.
The up-regulation of uPA (show PRAP1 ELISA Kits) mRNAs was correlated with high-risk clinicopathological features, including extrathyroid invasion, loss of cellular polarity/cohesiveness, and the BRAF (show BRAF ELISA Kits)(V600E) mutation.
In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 (show MMP9 ELISA Kits) by mesenchymal stromal cells.
The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
an intricate link between caveolin-1 (show CAV1 ELISA Kits) and Src kinase (show CSK ELISA Kits)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC ELISA Kits) expression through p53 (show TP53 ELISA Kits) and uPA system-mediated cross-talk, is reported.
These studies identify uPA-dependent de-repression of vegfr1 (show FLT1 ELISA Kits) and vegfr2 (show KDR ELISA Kits) gene transcription through binding to HHEX/PRH (show HHEX ELISA Kits) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (show VEGFA ELISA Kits) and identifies a potential new target for control of pathologic angiogenesis.
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
GM-CSF (show CSF2 ELISA Kits) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR ELISA Kits))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (show PLAT ELISA Kits) and/or PAI-1 (show SERPINE1 ELISA Kits), rather than an altered uPA expression, determines the plasmin (show PLG ELISA Kits)-mediated Abeta (show APP ELISA Kits) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (show PLAUR ELISA Kits)) and plasminogen activator inhibitor-1 (PAI-1 (show SERPINE1 ELISA Kits)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (show PLAUR ELISA Kits) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (show IRF6 ELISA Kits) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR ELISA Kits) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (show PLG ELISA Kits) activator/plasmin (show PLG ELISA Kits) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 ELISA Kits) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein