PLAU Products
(Plasminogen Activator, Urokinase (PLAU))
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This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
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Featured PLAU Categories
PLAU Antibodies
High quality antibodies with extensive validation data.
PLAU ELISA Kits
Reliable ELISA kits for a wide range of species.
PLAU Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PLAU Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), FACS
Validations
- (8)
- (4)
Cat. No.
ABIN1882148
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (5)
Cat. No.
ABIN185470
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, IF
Validations
- (6)
Cat. No.
ABIN3032244
Quantity
0.4 mL
Datasheet
Datasheet
Recommended PLAU ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (1)
Cat. No.
ABIN6958612
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958613
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969361
Quantity
96 tests
Datasheet
Datasheet
Recommended PLAU Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7275455
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275453
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275460
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PLAU products
: "Aptamer-Based Sandwich Assay Formats for Detection and Discrimination of Human High- and Low-Molecular-Weight uPA for Cancer Prognosis and Diagnosis." in: Cancers, Vol. 14, Issue 21, (2022) (PubMed).: "Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma." in: Oncotarget, Vol. 8, Issue 26, pp. 42300-42313, (2018) (PubMed).
: "Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy." in: Thrombosis research, Vol. 163, pp. 105-116, (2018) (PubMed).
: "Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro." in: Molecular medicine reports, Vol. 17, Issue 3, pp. 4273-4280, (2018) (PubMed).
: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." in: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).
: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." in: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).
: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).
: "Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC." in: Biochemical and biophysical research communications, Vol. 470, Issue 3, pp. 627-34, (2016) (PubMed).
: "1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway." in: International journal of oncology, Vol. 48, Issue 3, pp. 1271-9, (2016) (PubMed).
: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." in: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, (2016) (PubMed).
Synonyms and alternative names related to PLAU
plasminogen activator, urokinase (PLAU), urokinase-type plasminogen activator (CpipJ_CPIJ002131), urokinase-type plasminogen activator (CpipJ_CPIJ006543), urokinase-type plasminogen activator (CpipJ_CPIJ013396), urokinase-type plasminogen activator (CpipJ_CPIJ013623), plasminogen activator, urokinase (Plau), ATF, BDPLT5, PLAU, QPD, u-PA, UPA, uPA, UPAM, URKProtein level used designations for PLAU
- urokinase-type plasminogen activator
- U-plasminogen activator
- uPA
- plasminogen activator, urokinase
- plasminogen activator, urinary
- Urinary plasminogen activator, urokinase
- urokinase plasminogen activator preproprotein
Did you look for something else?
- Platelet-Derived Growth Factor CC
- Platelet-Activating Factor Acetylhydrolase 1b, Regulatory Subunit 1 (45kDa)
- Platelet Factor 3
- Platelet activating factor
- PLAT
- Plastin 3
- Plasmolipin
- Plasmodium Vivax MSP1
- Plasmodium Falciparum Histidine Rich Protein 2
- Plasmodium Falciparum
- Plasminogen Activator
- Plasmin/antiplasmin Complex
- Plasmin
- Plasmepsin-1
- PLAP
- Plakophilin 4
- Plakophilin 3
- Plakophilin 2
- Plakophilin 1
- PLAGL2
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