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Full name:: Scavenger Receptor Class B, Member 1 Proteins (SCARB1)

On www.antibodies-online.com are 16 Scavenger Receptor Class B, Member 1 (SCARB1) Proteins from 9 different suppliers available. Additionally we are shipping SCARB1 Antibodies (133) and SCARB1 Kits (28) and many more products for this protein. A total of 189 SCARB1 products are currently listed.

Synonyms:: AI120173, cb1015, CD36, Cd36l1, Cla-1, Cla1, D5Ertd460e, Hdlq1, HDLQTL6, Hlb398, mSR-BI, Scarb1, SR-B1, SR-BI, Srb1, SRBI

list all proteins	Gene Name	GeneID	UniProt
	SCARB1	949	Q8WTV0
	SCARB1	20778	Q61009
	SCARB1	25073	P97943
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Human Scavenger Receptor Class B, Member 1 (SCARB1) interaction partners

We demonstrate that 4F and Cl/NO2-HDL (show HSD11B1 Proteins) act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 ((-/-)) mouse aortic endothelial cells.
Our results demonstrate that SR-BI functions as an oncogene (show RAB1A Proteins) and promotes progression of clear cell renal cell carcinoma (show MOK Proteins) (ccRCC). SR-BI may serve as a potential prognostic biomarker and therapeutic target for ccRCC.
SCARB1 gene polymorphisms may serve as a potential predictor of treatment responses in chronic hepatitis C patients receiving interferon (show IFNA Proteins)-based therapy
The S112F single amino acid mutation in SR-BI inhibited the infectivity of hepatitis C virus derived from cell culture in a cell culture model by downregulating the expression of the SR-BI protein.
The cell surface receptor SR-BI (scavenger receptor class B member 1), is essential for hepatitis C virus (HCV) entry into hepatocytes. Variations in the gene coding this receptor influence infectivity and viral load. We analyzed these variations to gain a better understanding of inter-individual differences over the course of HCV infection.
The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL (show HSD11B1 Proteins) subfraction.
The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL (show HSD11B1 Proteins) subfraction.
These findings provide new insights into the role of SR-B1 in cellular cholesterol homeostasis and suggest molecular links between SR-B1-dependent lipid sensing and cell cholesterol and lipid droplet dynamics
Liposomes modified with both apolipoproteins A-I and E were internalized in HepG2 cells in FBS (show FBXO8 Proteins)-depleted culture medium at the same levels as unmodified liposomes in FBS (show FBXO8 Proteins)-containing culture medium, which indicates that apolipoproteins A-I and E were the major serum components involved in liposomal binding to SR-B1 or LDLR (show LDLR Proteins) (or both).
Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.

Mouse (Murine) Scavenger Receptor Class B, Member 1 (SCARB1) interaction partners

We demonstrate that 4F and Cl/NO2-HDL (show HSD11B1 Proteins) act on scavenger receptor type I (SR-B1) using human aorta endothelial cells (HAEC) and SR-B1 ((-/-)) mouse aortic endothelial cells.
These findings uncover a novel role for SR-B1 as a contributor to the capture of specific odorants in the nasal cavity of mammals.
In summary, the authors identified NAP1L1 (show NAP1L1 Proteins) as a novel binding partner of hepatitis c virus NS3 and found that the protease domain of NS3 is responsible for interactions with NAP1L1 (show NAP1L1 Proteins). They demonstrated the functional role of NAP1L1 (show NAP1L1 Proteins) in hepatitis c virus entry through regulating the protein expression of SR-B1.
SR-BI-triggered autophagy promoted co-elimination of apoptotic immune cells and dead bacteria but barely influenced bacterial sequestration and survival or inflammasome activation, thus exclusively counteracting damage inflicted by immune responses.
Overexpression of miR-24 inhibited SR-B1 expression by directly targeting SR-B1 3' UTR and repressed high density lipoprotein uptake and steroidogenesis in steroidogenic cells.
These data suggest that a moderate amount of alcohol plays a novel role in reverse cholesterol transport, mainly mediated by PPARgamma (show PPARG Proteins) and SR-B1.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 Proteins)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M (show A2M Proteins)), murinoglobulin double-knockout (DKO), and wild-type mice
Rutaecarpine was identified to be a candidate that protected ApoE (show APOE Proteins)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 (show ABCA1 Proteins) and SR-BI within RCT (show FOXE3 Proteins).
SR-B1 is a silica receptor associated with canonical inflammasome activation.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (show LPAR1 Proteins)/3 -AKT (show AKT1 Proteins) activation and subsequent SRBI expression.

Pig (Porcine) Scavenger Receptor Class B, Member 1 (SCARB1) interaction partners

Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes.

Cow (Bovine) Scavenger Receptor Class B, Member 1 (SCARB1) interaction partners

Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 (show ABCG1 Proteins) but not ABCA1 (show ABCA1 Proteins).

SCARB1 Protein Profile

Protein Summary

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SCARB1

scavenger receptor class B, member 1 (scarb1)
scavenger receptor class B member 1 (SCARB1)
scavenger receptor class B member 1 (Scarb1)
scavenger receptor class B member 1 (CpipJ_CPIJ014332)
scavenger receptor class B member 1 (CpipJ_CPIJ019101)
scavenger receptor class B, member 1 (Scarb1)

AI120173 protein
cb1015 protein
CD36 protein
Cd36l1 protein
Cla-1 protein
Cla1 protein
D5Ertd460e protein
Hdlq1 protein
HDLQTL6 protein
Hlb398 protein
mSR-BI protein
Scarb1 protein
SR-B1 protein
SR-BI protein
Srb1 protein
SRBI protein

Protein level used designations for SCARB1

scavenger receptor class B member 1 , scavenger receptor class B, member 1 , scavenger receptor class B type I , high density lipoprotein receptor SR-BI , CD36 and LIMPII analogous 1 , CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 , scavenger receptor class B type III , HDL QTL 1 , scavenger receptor class B1 , CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1) , SR-BI , scavanger receptor class B type 1 , SRB1 , CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1)

GENE ID	SPECIES
387260	Danio rerio
452359	Pan troglodytes
486241	Canis lupus familiaris
100009590	Oryctolagus cuniculus
100322870	Cavia porcellus
6047494	Culex quinquefasciatus
6053185	Culex quinquefasciatus
949	Homo sapiens
20778	Mus musculus
25073	Rattus norvegicus
416814	Gallus gallus
397018	Sus scrofa
282346	Bos taurus

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