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BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Proteins)) on the promoters of selected Notch (show NOTCH1 Proteins) target genes such as enhancer of split related 1.
Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR (show MLXIP Proteins)-10b could target the 3'-untranslated regions of B cell lymphoma 6 (Bcl6) which is an important regulator of osteoblast differentiation.
Def6 (show DEF6 Proteins) limits proliferation of T follicular helper cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.
The balance between CD4 (show CD4 Proteins)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (show TCF7 Proteins) (encoding TCF-1 (show HNF1A Proteins)) and by the expression of the inhibitory receptors PD-1 (show PDCD1 Proteins) and LAG3 (show LAG3 Proteins).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (show STAT1 Proteins).
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 Proteins) and the Ikaros (show IKZF1 Proteins) zinc finger transcription factors Aiolos (show IKZF3 Proteins) and Ikaros (show IKZF1 Proteins) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (show PRDM1 Proteins) control follicular helper T cell differentiation
both mouse and human B cells, IFN-gamma (show IFNG Proteins) synergized with B cell receptor, toll (show TLR4 Proteins)-like receptor, and/or CD40 (show CD40 Proteins) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.
observations reveal that KLF6 (show KLF6 Proteins) repress BCL6 to enhance macrophage inflammatory gene expression and function.
synergistic activity of Card11 (show CARD11 Proteins) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
our findings provide a novel apoptotic regulatory pathway in which LITAF (show LITAF Proteins), as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis.
Ikaros (show IKZF1 Proteins) regulates expression of the BCL6/BACH2 (show BACH2 Proteins) axis in acute lymphoblastic leukemia cells.
our work casts new light on the biology of mantle cell lymphoma (MCL (show FH Proteins)), revealing the role of SOX11 (show SOX11 Proteins) exerting a functional effect through the repression of BCL6 transcription in MCL (show FH Proteins) cells
BCL6 inhibitors have been shown to exert potent effects against these tumor types. Moreover, mechanism-based combinations of BCL6 inhibitors with other agents have yielded synergistic and often quite dramatic activity. Hence, there is a compelling case to accelerate the development of BCL6-targeted therapies for translation to the clinical setting
High BCL6 expression is associated with good response to chemotherapy in acute lymphoblastic leukemia.
this study show that PATZ1 (show ZNF278 Proteins) expression correlates positively with BAX (show BAX Proteins) and negatively with BCL6 and survival in human diffuse large B cell lymphomas
BCL6 expression is present in isolated cortical neurons, granule cells in the cerebellum, scattered glial cells, and in some cells of the ependyma and choroid plexus.
We show that human follicular lymphomas are dependent on BCL6
Aberrant BCL6 expression was strongly associated with poor reproductive outcomes in IVF (show SCN5A Proteins) cycles in women with unexplained infertility.
EBNA3C inhibits the transcriptional activity of the Bcl6 promoter through interaction with the cellular protein IRF4 (show IRF4 Proteins).
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S