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BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Proteins)) on the promoters of selected Notch (show NOTCH1 Proteins) target genes such as enhancer of split related 1.
this study shows that IL4 (show IL4 Proteins) and IL21 (show IL21 Proteins) cooperate to induce the high Bcl6 protein level required for germinal center formation
Although BCL6 controls follicular helper T cells activity in humans and mice, the role of miR (show MLXIP Proteins)-31 is restricted to human follicular helper T cell differentiation, reflecting a species specificity of the miR (show MLXIP Proteins)-31 action.
These findings indicate a role of the interaction between TH2-promoting factors and Bcl6 in promoting appropriate IL-4 (show IL4 Proteins) production in mTH2 (show NUDT15 Proteins) cells and suggest that chronic allergic diseases involve the TH2-promoting factor-mediated functional breakdown of Bcl6, resulting in allergy exacerbation.
Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR (show MLXIP Proteins)-10b could target the 3'-untranslated regions of B cell lymphoma 6 (Bcl6) which is an important regulator of osteoblast differentiation.
Def6 (show DEF6 Proteins) limits proliferation of T follicular helper cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.
The balance between CD4 (show CD4 Proteins)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (show TCF7 Proteins) (encoding TCF-1 (show HNF1A Proteins)) and by the expression of the inhibitory receptors PD-1 (show PDCD1 Proteins) and LAG3 (show LAG3 Proteins).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (show STAT1 Proteins).
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 Proteins) and the Ikaros (show IKZF1 Proteins) zinc finger transcription factors Aiolos (show IKZF3 Proteins) and Ikaros (show IKZF1 Proteins) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (show PRDM1 Proteins) control follicular helper T cell differentiation
BCL6 overexpression in SHR reduced blood pressure, NLRP3 expression and inflammation in the renal cortex of SHR
Aberrant CD10 (show MME Proteins) and BCL6 expression defines a subset of MCLs with higher mean Ki-67 (show MKI67 Proteins) index and higher prevalence of MUM1 (show IRF4 Proteins) expression
Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC (show MYC Proteins) rearrangement is present with either BCL2 (show BCL2 Proteins) or BCL6 rearrangement
BCL6 is a growth promoting factor in glioblastoma and glioma.
IFN gamma induced (show SAMHD1 Proteins) upregulation of BCL6 was dependent on the classical STAT1 (show STAT1 Proteins) signaling pathway, and affected both major BCL6 variants. Interestingly, although IFN alpha (show IFNA Proteins) induced stronger STAT1 (show STAT1 Proteins) phosphorylation than IFN gamma (show IFNG Proteins), it only slightly upregulated BCL6 in multiple myeloma lines.
Findings demonstrate that BCL6 expression is downregulated by miR (show MLXIP Proteins)-519d which targets its 3 '-UTR. Also, BCL6 mediates the repression of miR (show MLXIP Proteins)-519d on cell proliferation and invasive capability of gastric cancer cells.
In Pakistani population, the frequency of GCB (show GBA Proteins) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (show MME Proteins) and BCL6 is 37.5%, and non- GCB (show GBA Proteins) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 (show IRF4 Proteins) is 62.5%.
BCOR (show BCOR Proteins) internal tandem duplication and/or nuclear immunoreactivity for BCOR (show BCOR Proteins) or BCL6 can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.
our findings provide a novel apoptotic regulatory pathway in which LITAF (show LITAF Proteins), as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S