Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human BRD4 Antibodies:
anti-Mouse (Murine) BRD4 Antibodies:
anti-Rat (Rattus) BRD4 Antibodies:
Go to our pre-filtered search.
Human Polyclonal BRD4 Primary Antibody for IHC (p) - ABIN6242208
Kurg, Sild, Ilves, Sepp, Ustav: Association of bovine papillomavirus E2 protein with nuclear structures in vivo. in Journal of virology 2005
Show all 4 Pubmed References
Human Polyclonal BRD4 Primary Antibody for ICC, IF - ABIN438710
Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. in Molecular and cellular biology 2011
Show all 3 Pubmed References
Human Polyclonal BRD4 Primary Antibody for ICC, IF - ABIN4285227
Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. in Nature 2011
Show all 2 Pubmed References
Human Polyclonal BRD4 Primary Antibody for ChIP, WB - ABIN2668492
Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. in PLoS ONE 2013
Show all 2 Pubmed References
Human Polyclonal BRD4 Primary Antibody for IHC (p) - ABIN6242209
Gagnon, Joubert, Sénéchal, Fradet-Turcotte, Torre, Archambault: Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4. in Journal of virology 2009
Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
miR204 directly binds to UCA1 and the 3'untranslated region of BRD4. Furthermore, UCA1 competed with BRD4 for miR204 binding. miR204 knockdown enhanced BRD4 expression, which can be partially restored by short hairpinUCA1.
High BRD4 expression is associated with preeclampsia.
BRD4 silencing was negatively correlated palomid 529-induced apoptosis in the primary human renal cell carcinoma (show MOK Antibodies) cells and tumor growth in SCID (show PRKDC Antibodies) mice.
Study in melanoma cell and in vivo melanoma models provides evidence for a direct role of BRD4 binding at super-enhancers that drive the expression of PGC (show PGC Antibodies)-1alphaalpha and SOX10 (show SOX10 Antibodies), a transcription factor involved in melanocyte development.
miR (show MLXIP Antibodies)-608 inhibits hepatocellular carcinoma cell proliferation possibly via targeting BET family protein BRD4.
MS645 blocks BRD4 binding to transcription enhancer/mediator proteins MED1 (show MED1 Antibodies) and YY1 (show YY1 Antibodies) with potency superior to monovalent BET inhibitors, resulting in down-regulation of proinflammatory cytokines and genes for cell-cycle control and DNA damage repair that are largely unaffected by monovalent BrD inhibition.
Study shows that BRD4 is significantly highly expressed in gastric cancer patients and cell lines and positively regulates the expression of c-MYC (show MYC Antibodies) through transcription regulation and epigenetic levels. Functionally, these result demonstrate that the knockdown of BRD4 represses the proliferation and induces the apoptosis of gastric cancer cells through repression of c-MYC (show MYC Antibodies).
BRD4 hyperphosphorylation is associated with cellular transformation in NUT midline carcinoma
Results suggest structure-based drug design of bromodomain-containing protein 4 (Brd4) inhibitors.
Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (show PAX3 Antibodies)-FOXO1 (show FOXO1 Antibodies)-occupied super enhancers. Furthermore, PAX3 (show PAX3 Antibodies)-FOXO1 (show FOXO1 Antibodies) recruits and requires the BET bromodomain protein BRD4 to function at super enhancers, resulting in a complete dependence on BRD4 and a significant susceptibility to BRD inhibition
Brd4 deletion prevents enhancer RNA production, cell identity gene induction and cell differentiation. Interestingly, Brd4 is dispensable for maintaining cell identity genes in differentiated cells. These findings identify Brd4 as an enhancer epigenomic reader that links active enhancers with cell identity gene induction in differentiation.
results suggest that rhythmic expression of Sglt1 (show SLC5A1 Antibodies) is regulated at the mRNA transcriptional elongation level by enhancing the binding of the BRD4-P-TEFb (show CCNT1 Antibodies) complex to acetylated histones at the gene upon BMAL1 (show ARNTL Antibodies)-CLOCK binding to Sglt1 (show SLC5A1 Antibodies)
Bromodomain protein BRD4 promotes cell proliferation in skin squamous cell carcinoma.
By modulating the translation of IkappaBalpha (show NFKBIA Antibodies) via the Mnk2 (show MKNK2 Antibodies)-eIF4E (show EIF4E Antibodies) pathway, Brd4 provides an additional layer of control for NF-kappaB (show NFKB1 Antibodies)-dependent inflammatory gene expression and inflammatory response.
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 (show MAPK7 Antibodies) and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed.
Long-term treatment with bromodomain-containing protein 4 (BRD4) inhibitors caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.
Fmr1 (show FMR1 Antibodies) knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP (show FMR1 Antibodies), the reader protein Brd4, appears to be significantly involved in this transcriptional disruption.
The functional domains of mouse BRD4 and its role in transcription are described. Review.
Brd2 (show BRD2 Antibodies) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
These data provide a detailed mechanism for how activated NF-kappaB (show NFKB1 Antibodies) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Bromodomain-containing protein 4B
, bromodomain-containing protein 4B
, bromodomain containing 4
, bromodomain-containing protein 4
, bromodomain 4
, bromodomain-containing protein 4-like
, bromodomain containing protein 4
, bromodomain-containing 4
, chromosome-associated protein
, bromodomain-containing 5
, fsh-like protein
, mitotic chromosome-associated protein