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Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins)-occupied super enhancers. Furthermore, PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) recruits and requires the BET bromodomain protein BRD4 to function at super enhancers, resulting in a complete dependence on BRD4 and a significant susceptibility to BRD inhibition
Our data suggested that downregulation of BRD4 in gallbladder cancer (GBC) cells induced apoptosis by PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway. Inhibition of BRD4 expression may be a novel therapeutic strategy for patients with GBC.
these results highlighted the significant genetic contribution of the ARID1B variant, rs73013281, to susceptibility for HCC (show FAM126A Proteins), especially in interaction with physical activity.
In pluripotent cells, Brd2 (show BRD2 Proteins)-Brd4 occupy Nodal gene regulatory elements (NREs), but only Brd4 is required for pluripotency gene expression. Brd4 downregulation facilitates pluripotent exit and drives enhanced Brd2 (show BRD2 Proteins) NRE occupancy, thereby unveiling a specific function for Brd2 (show BRD2 Proteins) in differentiative Nodal-Smad2 (show SMAD2 Proteins) signalling
Findings reveal that PCa (show FLVCR1 Proteins)-associated ERG (show ERG Proteins) can interact and co-occupy with BRD4 in the genome, and suggest this druggable interaction is critical for ERG (show ERG Proteins)-mediated cell invasion and PCa (show FLVCR1 Proteins) progression.
Our data strongly support the use of CCR2 (show CCR2 Proteins) and CD180 (show CD180 Proteins) mRNAs as whole blood pharmacodynamic (PD)biomarkers for BRD4 inhibitors, especially in situations where paired tumor biopsies are unavailable. In addition, they can be used as tumor-based PD biomarkers for hematologic tumors.
Study identified Brd4 as a novel proline hydroxylation substrate with nearly 60% stoichiometry under normoxia states and its hydroxylation level is enzymatically regulated.
Further analysis indicated that JQ1 inhibited the recruitment of BDR4 to the promoter complex of the Myc (show MYC Proteins) and Ccnd1 (show CCND1 Proteins) genes in rat thyroid follicular PCCL3 cells, resulting in decreased MYC (show MYC Proteins) expression at the mRNA and protein levels to inhibit tumor cell proliferation
The Brd4 acetyllysine-binding protein of RelA (show NFkBP65 Proteins) is involved in activation of polyomavirus JC.
BRD4 phosphorylation regulates HPV E2-mediated viral transcription and cellular MMP-9 (show MMP9 Proteins) expression
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 (show MAPK7 Proteins) and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed.
Long-term treatment with bromodomain-containing protein 4 (BRD4) inhibitors caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.
Fmr1 (show FMR1 Proteins) knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP (show FMR1 Proteins), the reader protein Brd4, appears to be significantly involved in this transcriptional disruption.
The functional domains of mouse BRD4 and its role in transcription are described. Review.
Brd2 (show BRD2 Proteins) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
These data provide a detailed mechanism for how activated NF-kappaB (show NFKB1 Proteins) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.
DOT1L (show DOT1L Proteins), via dimethylated histone H3 (show HIST3H3 Proteins) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.
Acute induction of genes related to lipid accumulation in the livers of mice force-fed with fructose is associated with the induction of histone acetylation and BRD4 binding around these genes
Both mouse and human BRD4 have intrinsic histone acetyltransferase activity.
the interaction between BRD4 and Mediator has functional importance for gene-specific transcriptional activation and for acute myeloid leukemia (show BCL11A Proteins) maintenance.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Bromodomain-containing protein 4B
, bromodomain-containing protein 4B
, bromodomain containing 4
, bromodomain-containing protein 4
, bromodomain 4
, bromodomain-containing protein 4-like
, bromodomain containing protein 4
, bromodomain-containing 4
, chromosome-associated protein
, bromodomain-containing 5
, fsh-like protein
, mitotic chromosome-associated protein