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anti-Human IRF4 Antibodies:
anti-Mouse (Murine) IRF4 Antibodies:
anti-Rat (Rattus) IRF4 Antibodies:
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Human Polyclonal IRF4 Primary Antibody for ELISA, ICC - ABIN4327575
Nagel, Pommerenke, Meyer, Kaufmann, MacLeod, Drexler: NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia. in Oncotarget 1970
Dog (Canine) Polyclonal IRF4 Primary Antibody for WB - ABIN2780429
Han, Kraft, Nan, Guo, Chen, Qureshi, Hankinson, Hu, Duffy, Zhao, Martin, Montgomery, Hayward, Thomas, Hoover, Chanock, Hunter: A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. in PLoS genetics 2008
IRF4 is an independent prognostic factor for general MM patients.
Data show that the host transcript of miR (show MLXIP Antibodies)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (show BCL11A Antibodies).
Evidence for an essential role of Notch (show NOTCH1 Antibodies) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (show NOTCH1 Antibodies) signaling during CLL development.
These results show that significantly increased levels of FOXO3 (show FOXO3 Antibodies), IRF4, and xIAP (show XIAP Antibodies) mRNA in Chinese HIV-1-infected patients.
Mechanistically, we found that BETi-mediated inhibition of cMYC (show MYC Antibodies) correlates with the upregulation of miR (show MLXIP Antibodies)-125b-5p and the downregulation of the cMYC (show MYC Antibodies)/miR (show MLXIP Antibodies)-125b-5p target gene IRF4, a transcriptional repressor of MICA (show MICA Antibodies).
BCL7A (show BCL7A Antibodies), BRWD3 (show BRWD3 Antibodies), and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 (show TP53 Antibodies) and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations.
IRF4 protects arteries against neointima formation by promoting the expression of KLF4 (show KLF4 Antibodies) by directly binding to its promoter.
We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (show IRF7 Antibodies) upregulation.
GM-CSF (show CSF2 Antibodies) can mediate inflammation and pain by regulating IRF4-induced CCL17 (show CCL17 Antibodies) production
Nur77 (show NR4A1 Antibodies) suppresses CD4 (show CD4 Antibodies)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (show GATA3 Antibodies)(+) and IL-4 (show IL4 Antibodies)(+) cells.
Muramyl dipeptide reduces fat inflammation and liver insulin (show INS Antibodies) resistance via NOD2 (show NOD2 Antibodies). NOD1 (show NOD1 Antibodies)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (show INS Antibodies)-sensitizing effects of NOD2 (show NOD2 Antibodies), but not NOD1 (show NOD1 Antibodies), muropeptides.
Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.
IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.
The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (show GATA3 Antibodies), SATB1 (show SATB1 Antibodies), and IRF4.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (show FOXO1 Antibodies), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.
Here the authors show that concomitant loss of Tet2 (show TET2 Antibodies) and Tet3 (show TET3 Antibodies) in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igkappa locus.
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
interferon regulatory factor 4
, Interferon regulatory factor 4
, lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, PWWP domain-containing protein MUM1
, mutated melanoma-associated antigen 1