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In Pakistani population, the frequency of GCB (show GBA Proteins) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (show MME Proteins) and BCL6 (show BCL6 Proteins) is 37.5%, and non- GCB (show GBA Proteins) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 is 62.5%.
Study confirmed a significant role for IRF4 rs12203592 and SLC45A2 (show SLC45A2 Proteins) rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.
IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch (show NOTCH1 Proteins) signaling pathway.
IRF4 signaling is essential for activin A (show INHBA Proteins) induced regulatory T cells that restrain asthmatic responses.
The data indicate that USP4 (show USP4 Proteins) interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 (show IL4 Proteins) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.
IRF4 is an independent prognostic factor for general MM patients.
Data show that the host transcript of miR (show MLXIP Proteins)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (show BCL11A Proteins).
Evidence for an essential role of Notch (show NOTCH1 Proteins) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (show NOTCH1 Proteins) signaling during CLL development.
These results show that significantly increased levels of FOXO3 (show FOXO3 Proteins), IRF4, and xIAP (show XIAP Proteins) mRNA in Chinese HIV-1-infected patients.
Mechanistically, we found that BETi-mediated inhibition of cMYC (show MYC Proteins) correlates with the upregulation of miR (show MLXIP Proteins)-125b-5p and the downregulation of the cMYC (show MYC Proteins)/miR (show MLXIP Proteins)-125b-5p target gene IRF4, a transcriptional repressor of MICA (show MICA Proteins).
Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 (show FOXO1 Proteins) to both the Il9 (show IL9 Proteins) and Irf4 promoters and induces their transactivation.
MBD2 (show MBD2 Proteins) Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
study identifies IRF4 as central regulator of TH1 (show HAND1 Proteins) responses and cellular metabolism. We propose that this function of IRF4 is fundamental for the initiation and maintenance of all TH cell responses.
Nur77 (show NR4A1 Proteins) suppresses CD4 (show CD4 Proteins)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (show GATA3 Proteins)(+) and IL-4 (show IL4 Proteins)(+) cells.
Muramyl dipeptide reduces fat inflammation and liver insulin (show INS Proteins) resistance via NOD2. NOD1 (show NOD1 Proteins)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (show INS Proteins)-sensitizing effects of NOD2, but not NOD1 (show NOD1 Proteins), muropeptides.
Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.
IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.
The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (show GATA3 Proteins), SATB1 (show SATB1 Proteins), and IRF4.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, interferon regulatory factor 4
, Interferon regulatory factor 4
, PWWP domain-containing protein MUM1
, melanoma associated antigen (mutated) 1