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PAF supports glioma stem cells maintenance, in part, by influencing DNA replication and pyrimidine metabolism pathways.PAF-associated DNA translesion synthesis activity influences glioma stem cell radiation resistance.
KIAA0101 tv2 exerts anti-tumor activity in HCC (show FAM126A Proteins) and acts as an endogenous competitor of tumor-associated KIAA0101 tv1. KIAA0101 tv2 has a potential to work as a therapeutic drug targeting the KIAA0101 tv1 in HCC (show FAM126A Proteins).
High KIAA0101 expression is associated with kidney cancer.
The complex between p15PAF and trimeric PCNA (show PCNA Proteins) is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling.
miR (show MLXIP Proteins)-429 mediates deregulation of KIAA0101 by acting as an anti-metastatic miRNA that targets KIAA0101 pro-metastatic gene during metastasis of soft tissue sarcomas
PAF stimulation dose-dependently promoted the invasion, migration and growth of prostate cancer cells in vitro, while knockdow our findings demonstrate that PAFR (show PTAFR Proteins) can activate ERK1/2 pathway, and subsequently increase MMP-3 (show MMP3 Proteins) expression and decrease E-cadherin (show CDH1 Proteins) expression
High KIAA0101 level is associated with metastasis in hepatocellular carcinoma.
Results unveil an unsuspected role of the PAF-Wnt (show WNT2 Proteins) signalling axis in modulating cell plasticity, which is required for the maintenance of breast cancer cell stemness.
Results indicated that the expression of NS5ATP9 was up-regulated by starvation and that Beclin 1 (show BECN1 Proteins) was involved in autophagy induced in hepatoblastoma cells by starvation.
p15PAF acts as a flexible drag that regulates PCNA sliding along the DNA and facilitates the switch from replicative to translesion synthesis polymerase binding.
UHRF1 (show UHRF1 Proteins) ubiquitinates PAF15 at Lys (show LYZ Proteins) 15 and Lys (show LYZ Proteins) 24 and promotes its binding to PCNA (show PCNA Proteins) during late S-phase
PAF-induced ductal epithelial cell hyperproliferation was accompanied by extracellular signal-regulated kinase (ERK (show EPHB2 Proteins)) phosphorylation independently of Ras or Raf (show RAF1 Proteins) mutations.
Paf as a novel and essential regulator of early hematopoiesis.
highly restricted expression of the p15(PAF) gene in a spatio-temporal manner during embryogenesis
May be involved in protection of cells from UV-induced cell death.
HCV NS5A-transactivated protein 9
, PCNA-associated factor
, PCNA-associated factor of 15 kDa
, hepatitis C virus NS5A-transactivated protein 9
, overexpressed in anaplastic thyroid carcinoma 1
, uncharacterized protein LOC496365
, PCNA-associated factor-like
, HCV NS5A-transactivated protein 9 homolog