KIAA0101 Protein (His tag)

Catalog No. ABIN7317700

Product Details

Target: KIAA0101 (PAF) (PCNA Clamp Associated Factor (PAF))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KIAA0101 protein is labelled with His tag.

Purpose: Recombinant Human KIAA0101/p15/PAF Protein (His Tag)

Sequence: Met 1-Glu 111

Characteristics: A DNA sequence encoding the human PAF isoform 1 (NP_055551.1) (Met 1-Glu 111) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 97 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: KIAA0101 (PAF) (PCNA Clamp Associated Factor (PAF))

Alternative Name: KIAA0101/p15/PAF (PAF Products)

Synonyms: NS5ATP9 Protein, OEATC Protein, OEATC-1 Protein, OEATC1 Protein, PAF Protein, PAF15 Protein, p15(PAF) Protein, p15/PAF Protein, p15PAF Protein, paf Protein, Paf Protein, AA409629 Protein, Ns5apt9 Protein, Ns5atp9 Protein, mKIAA0101 Protein, Kiaa0101 Protein, PCNA clamp associated factor Protein, PCNA clamp associated factor S homeolog Protein, PCLAF Protein, pclaf Protein, pclaf.S Protein, Pclaf Protein

Background:

Background: KIAA0101, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor which interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners, and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA0101 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21 . KIAA0101 is involved in cell proliferation and plays a role in early tumor recurrence (ETR), and prognosis of hepatocellular carcinoma (HCC). KIAA0101 is expressed predominantly in liver, pancreas and placenta. It cannot be detected in heart or brain. It is highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas and in non-small-cell lung cancer lines. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. It also may be involved in protection of cells from UV-induced cell death.

Synonym: KIAA0101,L5,NS5ATP9,OEATC,OEATC-1,OEATC1,p15(PAF),p15/PAF,p15PAF,PAF,PAF15

Molecular Weight: 13.8 kDa

NCBI Accession: NP_055551

Pathways: Chromatin Binding