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anti-Rat (Rattus) MYB Antibodies:
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Human Monoclonal MYB Primary Antibody for WB - ABIN1944794
Majello, Kenyon, Dalla-Favera: Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. in Proceedings of the National Academy of Sciences of the United States of America 1987
Show all 3 Pubmed References
Human Polyclonal MYB Primary Antibody for IHC (p), IHC - ABIN253301
Clappier, Cuccuini, Kalota, Crinquette, Cayuela, Dik, Langerak, Montpellier, Nadel, Walrafen, Delattre, Aurias, Leblanc, Dombret, Gewirtz, Baruchel, Sigaux, Soulier: The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. in Blood 2007
Cow (Bovine) Polyclonal MYB Primary Antibody for ELISA, WB - ABIN4285666
Fahl, Crittenden, Allman, Bender: c-Myb is required for pro-B cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 2009
these results identify a key role for miR (show MLXIP Antibodies)-150 in memory CD8 (show CD8A Antibodies) T cells through a c-Myb-controlled enhanced survival circuit.
Myb knockdown in Setbp1 (show SETBP1 Antibodies) and Setbp1 (show SETBP1 Antibodies) missense mutations-induced AML (show RUNX1 Antibodies) cells also efficiently induced their differentiation in culture and significantly prolonged the survival of their secondary recipient mice.
These findings reveal miR (show MLXIP Antibodies)-301b as a new controller of inflammatory response by repressing c-Myb function to inhibit the anti-inflammatory response to bacterial infection, representing a novel mechanism for balancing inflammation.
The analysis points to a critical role for Hoxa9 (show HOXA9 Antibodies) and PU.1 in distal regulation of c-myb expression in murine myeloid cells during iL-6 (show IL6 Antibodies)-induced cell differentiation.
Data suggest that the upregulations of Myb and Peg3 (show PEG3 Antibodies) are likely the key anti-cancer events of EGCG in vivo.
deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Antibodies)- and NOTCH1 (show NOTCH1 Antibodies)-regulated genes, including the MYB and MYC (show MYC Antibodies) oncogenes, respectively.
MYB acts on MAPK (show MAPK1 Antibodies) signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2 (show SPRY2 Antibodies).
This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (show AKAP17A Antibodies) development to prevent mistimed dsDNA breaks and their deleterious consequences.
These results Myb as a critical component of the gene regulatory network controlling effector Treg cell differentiation and function.
Myb expands the ISC pool within which CRC (show SCRIB Antibodies) is initiated while co-operating with TSG (show TWSG1 Antibodies) loss
Both cases harbored the MYB-NFIB (show NFIB Antibodies) gene fusion as demonstrated by FISH and RNA-sequencing
Expression of c-Myb, a regulatory factor of B lymphocytes, is increased in B lymphocytes of AIHA/Evans patients, while miR (show MLXIP Antibodies)-150 expression is decreased. c-Myb was negatively correlated with miR (show MLXIP Antibodies)-150.
genome-wide association analyses identified a new genome-wide significant locus on the HBS1L (show HBS1L Antibodies)-MYB intergenic region for platelet-to-lymphocyte ratio
identified a high frequency of MYB rearrangements that promoted the MYB transcriptional activity in BPDCN. MYB split FISH analysis can constitute a valuable diagnostic tool for detecting MYB rearrangements
Studied association of BCL11A single nucleotide polymorphisms(snps) and HBS1L-MYB Intergenic snps with Hereditary Persistence of Fetal Hemoglobin (HPFH) in a cohort of sickle cell patients.
NFIB (show NFIB Antibodies)-associated gene rearrangement is a frequent genetic event in vulvar adenoid cystic carcinomas. Chromosome translocations involving NFIB (show NFIB Antibodies) but with an intact MYB indicate the presence of novel oncogenic mechanisms for the development of adenoid cystic carcinomas of the vulva.
Expression of the MYB-NFIB (show NFIB Antibodies) fusion oncogene (show RAB1A Antibodies) in mammary tissue resulted in hyperplastic glands that developed into adenocarcinoma.
A trend toward superior PFS was noted with the MYB/NFIB (show NFIB Antibodies) rearrangement, although this was not statistically significant. NGS revealed three tumors with 4q12 amplification, producing increased copies of axitinib-targeted genes PDGFR (show PDGFRB Antibodies)/KDR (show KDR Antibodies)/KIT.
Rearrangement of MYB did not affect OS.
Exosomes isolated from cultured AML (show RUNX1 Antibodies) or the plasma from mice bearing AML (show RUNX1 Antibodies) xenografts exhibited enrichment of miR (show MLXIP Antibodies)-150 and miR (show MLXIP Antibodies)-155. HSPCs cocultured with either of these exosomes exhibited impaired clonogenicity, through the miR (show MLXIP Antibodies)-150- and miR (show MLXIP Antibodies)-155-mediated suppression of the translation of transcripts encoding c-MYB
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
, Avian myeloblastosis viral (v-myb) oncogene homolog
, v-myb myeloblastosis viral oncogene homolog (avian)
, transcriptional activator Myb-like
, gag-myb protein
, myb proto-oncogene protein
, myeloblastosis proto-oncogene product
, proto-oncogene c-Myb
, transcriptional activator Myb
, tumor-specific myb protein
, c-myb protein (140 AA)
, DNA-binding transcriptional regulator
, c-myb proto-oncogene