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RASSF8 knockdown by specific RNAi showed similar effects in cervical cancer cells transfected with miR (show MLXIP Proteins)-224 mimic. Our findings suggest that miR (show MLXIP Proteins)-224 directly targets RASSF8 and thereby acts as a tumor promoter in cervical cancer progression
These results indicate that hypoxia-inducible miR (show MLXIP Proteins)-224 promotes gastric cancer cell growth, migration and invasion by downregulating RASSF8 and acts as an oncogene (show RAB1A Proteins), implying that inhibition of miR (show MLXIP Proteins)-224 may have potential as a therapeutic target for patients with hypoxic gastric tumors.
RASSF8 acts as a tumor suppressor in squamous cell carcinoma
RASSF8 plays a significant role in suppressing the progression of cutaneous melanoma.
RASSF8 as a tumor suppressor gene that is essential for maintaining AJs function in epithelial cells and have a role in epithelial cell migration.
Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12\;22)(p11.2\;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ras association domain-containing protein 8
, Ras association (RalGDS/AF-6) domain family 8
, carcinoma-associated protein HOJ-1
, carcinoma-associated protein HOJ-1 homolog