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study demonstrates that Piasy (show PIAS4 Proteins) may prevent exaggerated transcription of IFNI by Rbp2 (show KDM5A Proteins)-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses
Domain-swapped dimers of RBP2 (show KDM5A Proteins) provides evidence for ordered folding intermediates.
The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported.
Data show that CRBPI (show RBP1 Proteins) and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.
retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.
We report here the X-ray structures of human apo (show C9orf3 Proteins) and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II.
HNF-4alpha (show HNF4A Proteins) is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha (show HNF4A Proteins) in the regulation of human intestinal vitamin A absorption and metabolism
study demonstrates that Piasy (show PIAS4 Proteins) may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses
genetic deletion of RBP1 (show RBP1 Proteins) and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs (show SSU1 Proteins)) and amacrine type-2 (AII (show ARG2 Proteins)) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2 (show CA2 Proteins)+) channels, decreased and desynchronized evoked neurotransmitter release
The present study was designed to detect the expression of Histone H3 (show HIST3H3 Proteins) lysine 4 methylation and its demethylases LSD1 (show KDM1A Proteins), RBP2 and SMCX (show KDM5C Proteins) in 21-, 40- and 60-day-old mouse testes.
genetic ablation of Rbp2 decreases tumor formation and prolongs survival in Rb1(+/-) mice and Men1-defective mice.
RBP2 knockout mice have a higher rate of neonatal mortality and expression of CRBPII in the placenta
DGAT1 (show DGAT1 Proteins) is an important intestinal acyl-CoA:retinol acyltransferase; does not directly prevent retinol from being acted upon by DGAT1 (show DGAT1 Proteins) or other intestinal ARATs in vivo
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.
, cellular retinol-binding protein II
, retinol-binding protein 2
, retinol binding protein 2, cellular
, retinol-binding protein 2, cellular
, Retinol-binding protein 2 cellular
, Retinol-binding protein 2, cellular