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cDNA sequence determination, tissue-specific expression and gene linkage analysis
molecular dynamics simulations for the uptake of retinol by CRBP 1 and 2
study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses
Domain-swapped dimers of RBP2 provides evidence for ordered folding intermediates.
The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported.
With only nine point mutations, the hCRBPII mutants induced a systematic shift in the absorption profile of all-trans-retinal of more than 200 nanometers across the visible spectrum.
Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.
retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.
We report here the X-ray structures of human apo and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II.
HNF-4alpha is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha in the regulation of human intestinal vitamin A absorption and metabolism
genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release
RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes.
genetic ablation of Rbp2 decreases tumor formation and prolongs survival in Rb1(+/-) mice and Men1-defective mice.
RBP2 knockout mice have a higher rate of neonatal mortality and expression of CRBPII in the placenta
DGAT1 is an important intestinal acyl-CoA:retinol acyltransferase; does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.
, cellular retinol-binding protein II
, retinol-binding protein 2
, retinol binding protein 2, cellular
, retinol-binding protein 2, cellular
, Retinol-binding protein 2 cellular
, Retinol-binding protein 2, cellular