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Full name:: Splicing Factor 3b, Subunit 1, 155kDa Proteins (SF3B1)

On www.antibodies-online.com are 5 Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) Proteins from 4 different suppliers available. Additionally we are shipping SF3B1 Antibodies (75) and SF3B1 Kits (1) and many more products for this protein. A total of 92 SF3B1 products are currently listed.

Synonyms:: 155kDa, 2810001M05Rik, AA409119, hsh155, MDS, prp10, prpf10, Sap155, SF3B1, SF3b155, TA-8, Targ4, wu:fb99f09

list all proteins	Gene Name	GeneID	UniProt
	SF3B1	23451	O75533
	SF3B1	81898
Rat SF3B1	SF3B1	84486
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SF3B1 Proteins (SF3B1) by Origin

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Chromatin Binding

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Human Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

Prognostic interaction between bone marrow morphology and SF3B1 (show SF3B2 Proteins) and ASXL1 (show ASXL1 Proteins) mutations in myelodysplastic syndromes with ring sideroblasts.
SF3B1 (show SF3B2 Proteins) mutations were also associated with del(11q), which is prognostically different from inv (show INVS Proteins)(3)(q21q26.2)
Results find that SF3B1 (show SF3B2 Proteins) retained intron 4 (i4) harbors cryptic exons that are highly conserved and decoy exon E4e can promote intron retention at heterologous sites.
Integrated ERK1 (show MAPK3 Proteins)/ERK2 (show MAPK1 Proteins) response to B (show TDO2 Proteins)-cell receptor stimulation and SF3B1 (show SF3B2 Proteins) gene mutations refine prognosis in chronic lymphocytic leukemia.
could confirm the very good prognosis of MDS (show PAFAH1B1 Proteins) patients with del(11q) as described in the IPSS-R and identified a very high frequency of SF3B1 (show SF3B2 Proteins) mutations, a relatively low ASXL1 (show ASXL1 Proteins) and TP53 (show TP53 Proteins) mutation frequency, as well as a lack of EZH2 (show EZH2 Proteins) mutations as possible molecular reason for this favorable outcome
Our findings suggest that the genetic profile of coexistent GNAQ (show GNAQ Proteins) or GNA11 (show GNA11 Proteins) mutations with BAP1 (show RNF2 Proteins) or SF3B1 (show SF3B2 Proteins) mutations can aid the histopathological diagnosis of blue nevus-like melanoma and distinguish blue nevus-like melanoma from conventional epidermal-derived melanomas.
Mutation in SF3B1 (show SF3B2 Proteins) gene is associated with mucosal melanoma.
These data provide a catalog of copy-number associated gene dependencies and identify partial copy-loss of wild-type SF3B1 (show SF3B2 Proteins) as a novel, non-driver cancer gene dependency.
although blocking the function of SF3b elicits a massive accumulation of unspliced pre-mRNAs in the nucleus, intron-containing transcripts can still bind the ALYREF (show THOC4 Proteins) export factor and be transported to the cytoplasm, where they trigger an alternative nonsense-mediated decay pathway.
this study shows that DNMT3A (show DNMT3A Proteins) mutations are present in a significant proportion of SF3B1mut patients with RARS (show RARS Proteins) and its presence has a clearly negative impact on outcomes, determining a higher RBC (show CACNA1C Proteins) transfusion dependency, higher risk of progression to AML (show RUNX1 Proteins), and lower OS.

Mouse (Murine) Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

Our findings demonstrate that, despite significant differences in affected transcripts, there is overlap in the phenotypes associated with SF3B1-K700E between human and mouse.
Sf3b1(K700E) mice develop macrocytic anemia (show TCN2 Proteins) due to a terminal erythroid maturation defect, erythroid dysplasia, and long-term hematopoietic stem cell (LT-HSC (show FUT1 Proteins)) expansion.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Proteins)) activation of SF3B1 and SF3B1-mediated splice switching of KHK (show KHK Proteins)-A to KHK (show KHK Proteins)-C
Sf3b1 isrequired for the blastocyst formation.
SF3B1 plays an important role in the regulation of hematopoietic stem cells, whereas SF3B1 haploinsufficiency itself is not associated with the myelodysplastic syndrome phenotype with ring sideroblasts.
The level of Sf3b1 expression is critical for the proliferative capacity of hematopoietic stem cells. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.
the active spliceosome, containing SAP155 phosphorylated by DYRKIA, performs pre-mRNA splicing in spermatogonia during testicular development
active spliceosome, containing phosphorylated SAP155, performs pre-mRNA splicing on chromatin concomitant with transcription during testicular development.
Sf3b1 and Polycomb group (PcG) proteins interaction is essential for true PcG-mediated repression of Hox genes.

Zebrafish Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

Data indicate that splicing factor 3b (show SF3B14 Proteins), subunit 1 (sf3b1) mutation causes aberrant splicing of sf3b1 resulting in functional and predicted non-functional transcripts and a 90% reduction in full-length Sf3b1 protein.

SF3B1 Protein Profile

Protein Summary

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SF3B1

splicing factor 3b subunit 1 (SF3B1)
splicing factor 3b, subunit 1 (Sf3b1)
splicing factor 3b subunit 1 S homeolog (sf3b1.S)
splicing factor 3b subunit 1 (sf3b1)
splicing factor 3b, subunit 1 (sf3b1)
splicing factor 3b subunit 1 (Sf3b1)

155kDa protein
2810001M05Rik protein
AA409119 protein
hsh155 protein
MDS protein
prp10 protein
prpf10 protein
Sap155 protein
SF3B1 protein
SF3b155 protein
TA-8 protein
Targ4 protein
wu:fb99f09 protein

Protein level used designations for SF3B1

SAP 155 , pre-mRNA processing 10 , pre-mRNA splicing factor SF3b, 155 kDa subunit , spliceosome-associated protein 155 , splicing factor 3B subunit 1 , pre-mRNA-splicing factor SF3b 155 kDa subunit , splicing factor 3b, subunit 1, 155 kDa , transforming growth factor alpha regulated gene 4 , 146 kDa nuclear protein , SF3b155 , splicing factor 3b, subunit 1, 155kDa , splicing factor 3B subunit 1-like , splicing factor 3b, subunit 1, 155kD , tst

GENE ID	SPECIES
23451	Homo sapiens
81898	Mus musculus
399336	Xenopus laevis
424056	Gallus gallus
459850	Pan troglodytes
488456	Canis lupus familiaris
510177	Bos taurus
697773	Macaca mulatta
100022236	Monodelphis domestica
100070506	Equus caballus
100413687	Callithrix jacchus
100477819	Ailuropoda melanoleuca
100547422	Meleagris gallopavo
100559157	Anolis carolinensis
100604147	Nomascus leucogenys
84486	Rattus norvegicus
446117	Danio rerio
100723509	Cavia porcellus

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