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Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation.
TFAM is essential for transcription, replication and packaging of mtDNA into nucleoids. Tfam knockout mice display embryonic lethality secondary to severe mtDNA depletion. In this report, for the first time, we associate a homozygous variant in TFAM with a novel mtDNA depletion syndrome.
Tissue microarray (TMA) data showed that elevated expression of TFAM was related to the histological grade and TNM (show ODZ1 Proteins) stage of NSCLC patients.
The authors did not find statistically significant differences in the genotype frequencies for the TFAM +35G/C polymorphism between women with polycystic ovary syndrome and controls and found that mtDNA copy number is not associated with TFAM+35G/C SNP in polycystic ovary syndrome patients.
Alleles in mitochondrial transcription factor A (TFAM) and AP endonuclease 1 (APE1 (show APEX1 Proteins)) are associated with reduced cognitive performance.
In vivo, AICAR (show ATIC Proteins) significantly reduced osteosarcoma growth without apparent body weight loss and AICAR (show ATIC Proteins) increased both mitochondrial proliferation and apoptotic activity in treated tumor tissues. AICAR (show ATIC Proteins) showed anticancer effects in osteosarcoma cells through an AMPK (show PRKAA1 Proteins)-dependent peroxisome proliferatoractivated receptor-gamma coactivator-1alpha (PGC-1alpha)/mitochondrial transcription factor A (TFAM)/mitochondrial pathway
the present study identified the interaction of miR (show MLXIP Proteins)-590-3p and TFAM in colon cancer. TFAM was identified as a target of miR (show MLXIP Proteins)-590-3p, and miR (show MLXIP Proteins)-590-3p enhanced the proliferation of SW480 cells.
The results of the present study provided evidence that resistance to cisplatin chemotherapy in ERpositive breast cancer may be through TFAM and indicated that TFAM may be a target for chemoresistance in patients with breast cancer.
miR (show MLXIP Proteins)-199a-3p is able to attenuate cisplatin resistance in breast cancer cells through inhibiting TFAM expression.
We conducted a meta-analysis of studies involving CHAT, TFAM, and VR22 (show CTNNA3 Proteins) polymorphisms and Alzheimer disease susceptibility. For TFAM and VR22 (show CTNNA3 Proteins), no significant association was detected in studied single-nucleotide polymorphisms (SNPs).Rs1937 and rs2306604 of TFAM, are not significantly associated with AD risk.
TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.
Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.
de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Proteins) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.
Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis.
During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.
TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.
Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.
There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.
This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.
Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Proteins) release via RAGE (show AGER Proteins)- and TLR9 (show TLR9 Proteins)-responsive plasmacytoid dendritic cells.
overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Proteins)-overexpressing adipocytes
Acute exercise induces tumour suppressor protein p53 (show TP53 Proteins) translocation to the mitochondria and promotes a p53 (show TP53 Proteins)-Tfam-mitochondrial DNA complex in skeletal muscle.
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
transcription factor A, mitochondrial
, HMG box mitochondrial transcription factor
, mitochondrial transcription factor 1
, mitochondrial transcription factor A
, transcription factor 6
, transcription factor 6-like 1
, transcription factor 6-like 2 (mitochondrial transcription factor)
, transcription factor 6-like 3
, transcription factor 6-like 2
, testis-specific HMG-box protein m-tsHMG
, testis-specific high mobility group protein