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Data revealed that TFAM expression level was regulated by TP73-AS1/miR (show MLXIP Proteins)-200a axis in breast cancer cells.
Study clearly shows that hTFAM efficiently breaks the mitochondria-mediated vicious cycle in both Alzheimer's disease (AD) model neurons and mouse brains, resulting in an effective improvement of the AD pathophysiology including Abeta (show APP Proteins) accumulation and cognitive dysfunction.
these findings establish a new link between HIF-2alpha (show EPAS1 Proteins) and MAPK (show MAPK1 Proteins)-signaling that mediates the adaptive regulation of mitochondrial gene expression under low oxygen tension.
the results presented in this study obviously provided the evidence that TFAM was upregulated in glioma cell line and glioma tissue specimens. Therefore TFAM may be a novel diagnostic marker and therapeutic target for glioma and other cancer.
Biotinylated TMP interacts with TFAM.
TFAM polymorphisms (rs1937, rs1049432, and rs11006132) as well as their haplotypes did not show significant association with aggressiveness of prostate cancer in overweight or obese men.
results suggest a nucleation-cooperativity-based mechanism for sensitive detection of mitochondrial DNA and pathogen genomes, and identify HMGB (show FAH Proteins)/TFAM proteins as DNA-structuring host factors; they provide an explanation for the peculiar cGAS dimer structure and suggest that cGAS preferentially binds incomplete nucleoid-like structures or bent DNA
p53 (show TP53 Proteins) might incrase mtDNA copy number through its regulation on TFAM expression via TFAMpromoter.
TFAM is a gene regulator that acts to mitigate calcium mishandling and ROS (show ROS1 Proteins) production by wrapping around mitochondrial DNA complexes. TFAM's regulatory functions over serca2a (show ATP2A2 Proteins), NFAT (show NFATC1 Proteins), and Lon (show LONP1 Proteins) protease contribute to cardiomyocyte stability. [review]
The results suggest that a high mtTFA expression is a useful marker for tumor progression and a poor prognosis in left-sided colorectal cancer patients.
TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.
Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.
de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Proteins) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.
TFAM is essential for transcription, replication and packaging of mtDNA into nucleoids. Tfam knockout mice display embryonic lethality secondary to severe mtDNA depletion. In this report, for the first time, we associate a homozygous variant in TFAM with a novel mtDNA depletion syndrome.
Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis.
During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.
TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.
Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.
There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.
This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.
Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Proteins) release via RAGE (show AGER Proteins)- and TLR9 (show TLR9 Proteins)-responsive plasmacytoid dendritic cells.
overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Proteins)-overexpressing adipocytes
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
transcription factor A, mitochondrial
, HMG box mitochondrial transcription factor
, mitochondrial transcription factor 1
, mitochondrial transcription factor A
, transcription factor 6
, transcription factor 6-like 1
, transcription factor 6-like 2 (mitochondrial transcription factor)
, transcription factor 6-like 3
, transcription factor 6-like 2
, testis-specific HMG-box protein m-tsHMG
, testis-specific high mobility group protein