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Full name:: Complement Component 5a Proteins (C5a)

On www.antibodies-online.com are 20 Complement Component 5a (C5a) Proteins from 7 different suppliers available. Additionally we are shipping C5A Kits (104) and C5A Antibodies (62) and many more products for this protein. A total of 187 C5A products are currently listed.

Synonyms:: C5a, C5b, CPAMD4, Hc, RGD1561905

list all proteins	Gene Name	GeneID	UniProt
	C5a	727	P01031
	C5a	362119
	C5a
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Top referenced C5A Proteins

Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098 : Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)
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Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed)
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921 : Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005 (PubMed)
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More Proteins for C5A Interaction Partners

Human Complement Component 5a (C5a) interaction partners

recombinant C5a potentiated TNFalpha (show TNF Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation in renal tubular epithelial cells
tumoral C5a is an independent adverse prognostic biomarker for clinical outcome of Clear Cell Renal Cell Carcinoma (show MOK Proteins) patients after nephectomy.
C5a synergises with P. aeruginosa LPS (show IRF6 Proteins) in both PD-L1 (show CD274 Proteins) expression and the production of IL-10 (show IL10 Proteins) and TGF-beta (show TGFB1 Proteins).
Up-regulation of granulocyte and monocyte CD11b (show ITGAM Proteins) during plasma separation was C5-dependent.
This study provides the preclinical rationale for the combined blockade of PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) and C5a to restore antitumor immune responses, inhibit tumor cell growth, and improve outcomes of patients with lung cancer
Diagnosis and therapeutic management of neonatal hemochromatosis (show HFE Proteins) cannot only be based on C5b9 expression in liver samples as it is not specific of this disease.
C5a-C5aR enriched clear cell renal cell carcinoma (show MOK Proteins) patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21 (show CDKN1A Proteins)/p-p21 (show CDKN1A Proteins) expression via activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling.
Studies indicate that the complement response lie the active fragments, C3a (show C3 Proteins) and C5a, acting through their specific receptors, C3aR (show C3AR1 Proteins), C5aR1 (show C5AR1 Proteins) and C5aR2 to direct the cellular response to inflammation.

C5A (C5a) Protein Profile

Protein Summary

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

Alternative names and synonyms associated with C5A (C5a)

complement C5 (C5)

C5a protein
C5b protein
CPAMD4 protein
Hc protein
RGD1561905 protein

Protein level used designations for Complement Component 5a Proteins (C5a)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , complement C5 , prepro-C5 , anaphylatoxin

GENE ID	SPECIES
727	Homo sapiens
362119	Rattus norvegicus

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Show all Complement Component 5a Proteins (C5a) with Pubmed References

Human Complement Component 5a (C5a) interaction partners

Protein Summary

Alternative names and synonyms associated with C5A (C5a)

Protein level used designations for Complement Component 5a Proteins (C5a)