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anti-Human Kallikrein 5 Antibodies:
anti-Mouse (Murine) Kallikrein 5 Antibodies:
anti-Rat (Rattus) Kallikrein 5 Antibodies:
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Human Polyclonal Kallikrein 5 Primary Antibody for WB - ABIN390305
Planque, de Monte, Guyetant, Rollin, Desmazes, Panel, Lemarié, Courty: KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer. in Biochemical and biophysical research communications 2005
Show all 3 Pubmed References
Human Polyclonal Kallikrein 5 Primary Antibody for ELISA, WB - ABIN188845
Michael, Pampalakis, Mikolajczyk, Malm, Sotiropoulou, Diamandis: Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression. in The Journal of biological chemistry 2006
persistently upregulated KLK5 resulted in atopic dermatitis-like skin architecture and secretion of atopic dermatitis-related cytokines from keratinocytes in a PAR2 (show F2RL1 Antibodies) independent manner
It may be considered that circulating kallikrein 5 is down-regulated in chronic spontaneous urticaria patients, however its potential role and the possible underlying mechanism are unknown.
Thus, these findings point to the involvement of KLK5 in the proteolytic activation and spread of seasonal influenza viruses in humans.
The results of the present study indicated that the mRNA and protein expression levels of KLK5 were significantly upregulated in CRC (show CALR Antibodies) tissues and sera, and were associated with an advanced tumor stage.
the expression level of hK5 in tumor stromal cells is a promising biomarker for poor prognosis in TNBC.
This report demonstrates that concurrent loss of KLK5 and KLK7 (show KLK7 Antibodies) associates with a poor clinical outcome in Oral Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease.
Low KLK5 expression is associated with breast cancer.
KLK5 is an important contributor to the Netherton syndrome (show SPINK5 Antibodies) proteolytic cascade.
Data indicate that the KLK5 SNP rs268908 was associated with an increased risk of prostate cancer.
Kallikrein 5 and kallikrein 12 (show KLK12 Antibodies) cleave human influenza hemagglutinins and activate thrombolytic zymogens.
Ablation of KLK5 is not sufficient to rescue the lethal effect of LEKTI (show SPINK5 Antibodies)-deficiency. Double deficiency of both KLK5 and KLK7 (show KLK7 Antibodies) completely rescues Netherton Syndrome (show SPINK5 Antibodies)-like phenotype.
the pruritogenic action of KLK5 may be primarily mediated by PAR2 (show F2RL1 Antibodies) receptors
findings illustrate the crucial role of protease regulation in skin homeostasis and inflammation, and establish KLK5 inhibition as a major therapeutic target for NS
The cloning and characteriazation of recombinant Klk5 is reported.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
, kallikrein-like protein 2
, stratum corneum tryptic enzyme
, Kallikrein 1 renal/pancreas/salivary