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Human Kallikrein 6 Protein expressed in Wheat germ - ABIN1308867
Ashby, Kehoe, Love: Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia. in Brain research 2010
KLK6 (show KLK1 Proteins)-PAR2 (show F2RL1 Proteins) expression is down-regulated and PAR1 (show MARK2 Proteins) is up-regulated when DeltaNp63beta expression is decreased, leading to EMT (show ITK Proteins) with enhancing migration and invasion through ERK (show EPHB2 Proteins) signal reduction at the invasive front
KLK6 (show KLK1 Proteins) may be the key protease involved in the proteolytic modification of PFK-M (show PFKM Proteins).
Our data demonstrate for the first time increased levels of KLK6 (show KLK1 Proteins) in mucosal melanomas of the head and neck
Induction of autophagic processes through KLK6 (show KLK1 Proteins) expression may increase acquisition of resistance of gastric cancer cells to auranofin-induced autophagy.
Our data provide experimental evidence that KLK6 (show KLK1 Proteins) controls metastasis formation in colon cancer via specific downstream network of miRNA-mRNA effectors.
Data show that kallikrein 6 (KLK6) expression is induced in mouse and human skin during chronic glucocorticoid treatment.
FST (show FST Proteins) and KLK6 (show KLK1 Proteins) may have significance in breast cancer detection
KLK6 (show KLK1 Proteins) overexpression and likely its proteolytic activity is associated with alterations in downstream miRNAs and their targets, and these differ with the molecular subtypes of breast cancer.
Molecular models of peptides were built into the KLK6 (show KLK1 Proteins) structure and the marked preference of the cut between the two R of the examined peptides was related to the extended conformation of the substrates
Our fine-mapping study has identified novel loci in the KLK6 (show KLK1 Proteins) region strongly associated with aggressive PCa (show FLVCR1 Proteins).
Kallikrein 6 (show KLK1 Proteins) secreted by oligodendrocytes plays a critical role in the pathogenesis of experimental autoimmune encephalomyelitis.
Data show that kallikrein 6 (KLK6 (show KLK1 Proteins)) expression is induced in mouse and human skin during chronic glucocorticoid treatment.
Klk6 (show KLK1 Proteins) represents an important target for conditions in which pro-inflammatory responses play a critical role in disease development, including MS
KLK6 (show KLK1 Proteins) protein from 129 mice showed reduced SDS (show SDS Proteins)-PAGE mobility compared with that from C57BL/6 mice; recombinant KLK6 (show KLK1 Proteins) protein from 129 mice had a higher optimum pH and >15 times higher hydrolytic enzymatic activity for several substrates than that from C57BL/6 mice. These results suggest that KLKs may contribute to the genetic basis of the differences between mouse strains.
these data point to a novel kallikrein 6 (show KLK1 Proteins) -signaling axis in neurons that is mediated by PAR1 (show F2R Proteins) and PAR2 (show F2RL1 Proteins) and is positioned to contribute to neurodegeneration
These results indicate that KLK6 (show KLK1 Proteins) plays a functional role in oligodendrocyte development and the expression of myelin proteins.
Neuropathological analysis following delivery of LV-Neurosin to alpha-syn tg mice resulted in reduced accumulation of alpha-syn and reversal of neurodegenerative alterations in wild type but not A53T alpha-syn tg mice
We have found an increase in the level of neurosin, a key negative regulator of SNCA in the Ts65Dn mouse model for Down syndrome
KLK6 (show KLK1 Proteins) is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis
Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 (show KLK1 Proteins) in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 (show F2RL1 Proteins) in the late stages of wound healing.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
, protease M
, serine protease 18
, serine protease 9
, kallikrein 6 (neurosin)
, kallikrein 6 (neurosin, zyme)
, protease serine 9 (neurosin)
, protease, serine, 9
, brain serine protease
, kallikrein 29
, kallikrein 6
, myelencephalon-specific protease
, myofibril-bound protease
, protease, serine, 18