Browse our KLKB1 Proteins (KLKB1)

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

• kallikrein B1 (KLKB1)
• kallikrein B, plasma 1 (Klkb1)
• kallikrein B1 (Klkb1)
• plasma kallikrein (CpipJ_CPIJ004042)
• plasma kallikrein (CpipJ_CPIJ014955)
• Show all gene names
• plasma kallikrein (CpipJ_CPIJ020108)
• Plasma kallikrein (VAA_02266)
• kallikrein B, plasma (Fletcher factor) 1 (KLKB1)
• coagulation factor XI (LOC100549617)
• kallikrein B1 (klkb1)
• kallikrein B1 L homeolog (klkb1.L)

• APS protein
• DKFZp459J2015 protein
• Kal-3 protein
• Kal3 protein
• Kalp1 protein
• Show all synonym aliases
• KALP15 protein
• Klk3 protein
• klkb1 protein
• PPK protein
• PSA protein

Fletcher factor , kininogenin , plasma kallikrein , plasma kallikrein heavy chain , plasma kallikrein light chain , plasma prekallikrein , antigen, prostate specific , fletcher factor , kallikrein 3, plasma , kallikrein B, plasma (Fletcher factor) 1 , Plasma kallikrein , plasma kallikrein-like , plasma kallikrein B1