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Plasma kallikrein (PLK)-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer.
genetic polymorphism is associated with C1 Inhibitor (show SERPING1 Proteins) deficiency angioedema age of onset in European families
these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease-activated receptor 1 (show F2R Proteins)
von Willebrand factor (show VWF Proteins) activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.
KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia.
Genotyping these subjects revealed that the carriers of the minor alleles at the two loci- F12 (show F12 Proteins) and KLKB1 had a significant association with reduced levels of active plasma renin (show REN Proteins).
2 genetic loci (kininogen 1 (show KNG1 Proteins) and kallikrein (show KLK4 Proteins) B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein (show KLK4 Proteins)-kinin system and the RAAS.
PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation.
FXI (show F11 Proteins) may have a role in risk of ischemic stroke, but not myocardial infarct; FXII (show F12 Proteins) and prekallikrein may not have a role in either
plasma kallikrein and FXIa activate pro-HGF (show HGF Proteins) in vitro
Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator (show PLAT Proteins) therapy in mice after stroke.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3 (show PSA Proteins)) and other kallikrein (show KLK1 Proteins)-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (show MAS1 Proteins), prostacyclin, Sirt1 (show SIRT1 Proteins), and KLF4 (show KLF4 Proteins)
Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.
PKK (show RIPK4 Proteins) or fXII (show F12 Proteins) deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis.
Data suggest that LGG secreting PSA (show NPEPPS Proteins) may activate antigen specific immune responses when instilled intravesically and IL15 (show IL15 Proteins) could enhance this response.
the prekallikrein gene (Klkb1) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution.
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
, plasma kallikrein
, plasma kallikrein heavy chain
, plasma kallikrein light chain
, plasma prekallikrein
, antigen, prostate specific
, fletcher factor
, kallikrein 3, plasma
, kallikrein B, plasma (Fletcher factor) 1
, Plasma kallikrein
, plasma kallikrein-like
, plasma kallikrein B1