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KLKB1 Products

(Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008].

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Featured KLKB1 Categories

KLKB1 Antibodies

High quality antibodies with extensive validation data.

KLKB1 ELISA Kits

Reliable ELISA kits for a wide range of species.

KLKB1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KLKB1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6262852
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (3)
Cat. No. ABIN7256830
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (2)
Cat. No. ABIN7187793
Quantity 100 μg
Datasheet Datasheet

Recommended KLKB1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6976253
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6976057
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975157
Quantity 96 tests
Datasheet Datasheet

Recommended KLKB1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275096
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275094
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275098
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our KLKB1 products

Lee, Joo, Lim, Park, Lee, Park, Seok, Lee, Kang: "Proteomic analysis of serum from patients with major depressive disorder to compare their depressive and remission statuses." in: Psychiatry investigation, Vol. 12, Issue 2, pp. 249-59, (2015) (PubMed).

Tang, Yu, Williams, Springman, Jeffery, Sprengeler, Estevez, Sampang, Shrader, Spencer, Young, McGrath, Katz: "Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein." in: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 41077-89, (2005) (PubMed).

Synonyms and alternative names related to KLKB1

kallikrein B1 (KLKB1), kallikrein B, plasma 1 (Klkb1), kallikrein B1 (Klkb1), plasma kallikrein (CpipJ_CPIJ004042), plasma kallikrein (CpipJ_CPIJ014955), plasma kallikrein (CpipJ_CPIJ020108), Plasma kallikrein (VAA_02266), kallikrein B, plasma (Fletcher factor) 1 (KLKB1), coagulation factor XI (LOC100549617), kallikrein B1 (klkb1), kallikrein B1 L homeolog (klkb1.L), APS, DKFZp459J2015, Kal-3, Kal3, Kalp1, KALP15, KLK3, Klk3, KLKB1, klkb1, PPK, PSA

Protein level used designations for KLKB1

  • Fletcher factor
  • kininogenin
  • plasma kallikrein
  • plasma kallikrein heavy chain
  • plasma kallikrein light chain
  • plasma prekallikrein
  • antigen, prostate specific
  • fletcher factor
  • kallikrein 3, plasma
  • kallikrein B, plasma (Fletcher factor) 1
  • Plasma kallikrein
  • plasma kallikrein-like
  • plasma kallikrein B1
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