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Folate receptor beta as a novel CD11b/CD18 (show ITGAM Proteins) regulator for trafficking and homing of a subset of macrophages on collagen.
we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1 (show FOLR1 Proteins), FOLR2, CD68 (show CD68 Proteins) and CD11b (show ITGAM Proteins) markers
FR-beta expression was low or absent in the majority of ovarian, breast and colorectal tumor samples.
FR-beta is uniquely expressed on this proinflammatory subpopulation offers a new strategy to suppress migration of inflammatory monocytes into sites of inflammation.
The FRalpha gene was expressed in all parathyroid cells analyzed, and the FRbeta gene was expressed by most.
High FOLR2 mRNA expression is associated with uraemic patients on hemodialysis.
severe pre-eclampsia is associated with decreased placental expression of FR-beta and a reduction in the number of fetal macrophages (Hofbauer cells)
Expression of folate receptor-beta on activated macrophages holds a promising potential for early diagnosis of atherosclerosis. (Review)
High Folate Receptor beta expressing tumor-associated macrophages are associated with pancreatic cancer.
Functional FR-beta present on osteoarthritis synovial macrophages provides a potential tool for the diagnosis and treatment of this disease.
The characteristics of folate transport in oocytes are consistent with folate receptor (show FOLR3 Proteins)-mediated endocytosis, possibly by the FOLR2 isoform.
FRbeta expression was markedly increased in lung macrophages at 48 hours after intratracheal LPS (show TLR4 Proteins).
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 (show SLC46A1 Proteins) were not detected in 2-cell embryos and blastocysts.
Folbp2 null cells display increased sensitivity to arsenic exposure
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
folate receptor 2 (fetal)
, folate receptor beta
, folate receptor, beta
, folate receptor, fetal/placental
, folate-binding protein, fetal/placental
, placental folate-binding protein
, folate binding protein 2
, folate-binding protein 2