Browse our anti-Solute Carrier Family 19, Member 3 (Slc19a3) Antibodies

Full name:: anti-Solute Carrier Family 19, Member 3 Antibodies (Slc19a3)

On www.antibodies-online.com are 36 Solute Carrier Family 19, Member 3 (Slc19a3) Antibodies from 13 different suppliers available. Additionally we are shipping Solute Carrier Family 19, Member 3 Proteins (4) and and many more products for this protein. A total of 46 Solute Carrier Family 19, Member 3 products are currently listed.

Synonyms:: A230084E24Rik, AI788884, BBGD, MGC52872, MGC89434, si:dkey-223n17.4, slc19a3, THMD2, ThTr2

list all antibodies	Gene Name	GeneID	UniProt
	Slc19a3	80704	Q9BZV2
	Slc19a3	316559
	Slc19a3	80721	Q99PL8
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Most Popular Reactivities for anti-Solute Carrier Family 19, Member 3 (Slc19a3) Antibodies

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anti-Human Antibodies:

34 WB Antibodies

anti-Rat (Rattus) Antibodies:

3 WB Antibodies

anti-Mouse (Murine) Antibodies:

7 WB Antibodies

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Relevant Pathways for anti-Solute Carrier Family 19, Member 3 Antibodies

Dicarboxylic Acid Transport

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Top referenced anti-Solute Carrier Family 19, Member 3 Antibodies

Human Polyclonal Slc19a3 Primary Antibody for WB - ABIN4893259 : Schänzer, Döring, Ondrouschek, Goos, Garvalov, Geyer, Acker, Neubauer, Hahn: Stress-induced upregulation of SLC19A3 is impaired in biotin-thiamine-responsive basal ganglia disease. in Brain pathology (Zurich, Switzerland) 2014 (PubMed)

More Antibodies against Solute Carrier Family 19, Member 3 Interaction Partners

Human Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

two siblings who received a refined diagnosis of BTBGD following whole-genome sequencing. Both children inherited compound heterozygous mutations from unaffected parents; a missense single-nucleotide variant (p.G23V) in the first transmembrane domain of the protein, and a 4808-bp deletion in exon 1 encompassing the 5' UTR (show UTS2R Antibodies) and minimal promoter region.
Using aggregated exome sequencing data, we calculate the carrier frequency of mutations in SLC19A3 as 1 in 232 individuals in the general population, for an estimated prevalence of the disease of approximately 1 in 215,000 individuals. The disease is thus more frequent than previously recognized
Genetic variations in SLC19A3 play an important role in the pathogenesis of severe diabetic retinopathy and nephropathy and may explain why some individuals with type 1 diabetes are less prone than others to develop microvascular complications.
Genetic screening of SLC19A3 mutation is crucial to diagnosis autosomal recessive biotin-thiamine-responsive basal ganglia disease in asymptomatic relatives presenting with unexplained subacute encephalopathy and abnormal movements.
The direct binding and activation of SLC19A3 expression by HIF-1alpha (show HIF1A Antibodies) during hypoxic stress
The mutation of SLC19A3 is related to Biotin-thiamine-responsive basal ganglia disease.
Species differences in the substrate specificity of THTR-2 between human and mouse orthologues were observed.
large genomic deletions occur in the regulatory region of SLC19A3 in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy
Genetic variation in the SLC19A3 thiamine transporter at 2:228563818T/C may make a modest contribution towards the genetic susceptibility to alcohol dependence syndrome.
This study provided evidence that biotin-thiamine-responsive basal ganglia disease is the result of SLC19A2 (show SLC19A2 Antibodies) mutation.

Mouse (Murine) Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

showed that acute neurodegeneration caused by thiamine deficiency is preventable in most parts, and prompt high-dose thiamine administration is critical for the treatment of THMD2. However, reduction of thiamine should be performed carefully to prevent recurrence after recovery of the disease
THTR-2 is required for normal uptake of thiamin in the intestine and can fulfill normal levels of uptake in conditions associated with THTR-1 (show DDA1 Antibodies) dysfunction.
Pancreatic beta cells and islets take up thiamine by a regulated THTR1 (show DDA1 Antibodies)/2-mediated process.

Solute Carrier Family 19, Member 3 (Slc19a3) Antigen Profile

Antigen Summary

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD)\; a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.

Alternative names and synonyms associated with Solute Carrier Family 19, Member 3 (Slc19a3)

solute carrier family 19 member 3 (SLC19A3) antibody
solute carrier family 19 member 3 (Slc19a3) antibody
solute carrier family 19 member 3 L homeolog (slc19a3.L) antibody
solute carrier family 19 (thiamine transporter), member 3 (slc19a3) antibody
thiamine transporter 2 (LOC486151) antibody
solute carrier family 19 (thiamine transporter), member 3b (slc19a3b) antibody
solute carrier family 19, member 3 (SLC19A3) antibody
thiamine transporter 2-like (LOC100230080) antibody
solute carrier family 19, member 3 (Slc19a3) antibody

A230084E24Rik antibody
AI788884 antibody
BBGD antibody
MGC52872 antibody
MGC89434 antibody
si:dkey-223n17.4 antibody
slc19a3 antibody
THMD2 antibody
ThTr2 antibody

Protein level used designations for Slc19a3

solute carrier family 19, member 3 , thTr-2 , thiamine transporter 2 , solute carrier family 19 (sodium/hydrogen exchanger), member 3 , thiamine transporter 2-like

GENE ID	SPECIES
80704	Homo sapiens
316559	Rattus norvegicus
379156	Xenopus laevis
424792	Gallus gallus
448431	Xenopus (Silurana) tropicalis
470667	Pan troglodytes
486151	Canis lupus familiaris
537280	Bos taurus
556920	Danio rerio
709554	Macaca mulatta
100230080	Taeniopygia guttata
100341170	Oryctolagus cuniculus
100445161	Pongo abelii
80721	Mus musculus
100731585	Cavia porcellus

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Show all anti-Solute Carrier Family 19, Member 3 (Slc19a3) Antibodies with Pubmed References

Human Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

Mouse (Murine) Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

Antigen Summary

Alternative names and synonyms associated with Solute Carrier Family 19, Member 3 (Slc19a3)

Protein level used designations for Slc19a3