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single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I (show LIG1 Proteins)
Role of LRIG3 in cancer [review]
This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2 (show DCTN2 Proteins), DNAH10, LRIG3, and MYO1A (show MYO1A Proteins) has been linked to an inherited neuropathy in humans.
The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.
A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (show XRCC1 Proteins) gene on binding interaction of XRCC1 (show XRCC1 Proteins) protein with ligase III.
In the context of tyrosine kinase (show TXK Proteins)-activated leukemias, c-MYC (show MYC Proteins) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (show PARP1 Proteins) up-regulation.
LRIG3 functions as a tumor suppressor by attenuating EGFR (show EGFR Proteins) signaling pathway.
LRIG3 plays an important role in Hela229 cell proliferation, apoptosis, and invasiveness.
there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4 (show LIG4 Proteins)), to facilitate the escape from a telomere-driven crisis.
The results on expression of other tumor markers suggest that LRIG3 is influenced by or influences a pattern of tumor markers in cancer and precancerous cells.
Telomere-internal double-strand breaks (DSBs) are also repaired by a PARP1- and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs.
Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.
data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (show ATM Proteins) in regulating DNA Lig3 stability and consequently mtDNA repair
Lig3 has an essential role in mtDNA maintenance but is dispensable for the viability of cultured cells
data reveal that the critical biological role of Lig3 is to maintain mtDNA integrity and not Xrcc1 (show XRCC1 Proteins)-dependent DNA repair
results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (show XRCC1 Proteins)
Early embryonic lethality is due to targeted inactivation of DNA ligase III.
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
DNA ligase III
, ligase III, DNA, ATP-dependent
, DNA ligase (ATP) 3
, DNA ligase 3
, ligase II, DNA, ATP-dependent
, polydeoxyribonucleotide synthase [ATP] 3
, DNA ligase 3 isoform alpha
, leucine-rich repeats and immunoglobulin-like domains protein 3
, DNA ligase 3-like
, DNA ligase III isoform alpha
, ligase III, DNA, ATP-dependent L homeolog