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Human Polyclonal MCM4 Primary Antibody for IHC, PLA - ABIN151756
Song, Lafont, Chen, Wu, Shirahige, Rankin: Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery. in The Journal of biological chemistry 2012
MCM4 and MCM7 (show MCM7 Antibodies) expression is significantly correlated with Ki-67 (show MKI67 Antibodies), Bmi1 (show BMI1 Antibodies), and cyclin E (show CCNE1 Antibodies) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase (show DNAH8 Antibodies) activities to the complex containing wild-type MCM4
Mutant p53 (show TP53 Antibodies) depletion profoundly influenced PARP1 (show PARP1 Antibodies) localization and increased the level of PCNA (show PCNA Antibodies) and MCM4 proteins.
Of the total, the deregulation of several genes (CDK1 (show CDK1 Antibodies), CDK2 (show CDK2 Antibodies), CDK4 (show CDK4 Antibodies), MCM2 (show MCM2 Antibodies), MCM3 (show MCM3 Antibodies), MCM4, EIF3a (show EIF6 Antibodies) and RPN2 (show PSMD1 Antibodies)) were potentially associated with disease development and progression.
Mcm2-7 (show MCM2 Antibodies) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Peroxisome proliferator-activated receptor gamma (show PPARG Antibodies) coactivator 1beta (PGC-1beta (show PPARGC1B Antibodies)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
point mutation of MCM4 perturbs proper interaction with MCM6 (show MCM6 Antibodies) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (show MCM2 Antibodies) complex
Mutations in MCM4/PRKDC (show PRKDC Antibodies) represent a novel cause of DNA breakage and NK cell deficiency.
Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
role of subunits in DNA helicase acdtivity
Substrate preference and helicase (show DNA2 Antibodies) actions of mouse MCM4/6/7 helicase (show DNA2 Antibodies) complexes.
MCM4 phosphorylation by Cdc7 (show CDC7 Antibodies) kinase facilitates its interaction with Cdc45 (show CDC45 Antibodies) on chromatin
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
Loss of one allele of cdc2l (show CDK13 Antibodies) genefacilitates carcinogen-induced skin carcinogenesis in vivo.
Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (show MCM2 Antibodies) complex, causing impaired DNA replication and may have a causative role in cancer development.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
DNA replication licensing factor mcm4
, MCM4 minichromosome maintenance deficient 4
, minichromosome maintenance protein 4
, DNA replication licensing factor MCM4
, CDC21 homolog
, homolog of S. pombe cell devision cycle 21
, minichromosome maintenance deficient 4
, mini chromosome maintenance deficient 4 homolog
, minichromosome maintenance deficient 4 homolog