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miR (show MLXIP Proteins)-198 decreased the protein expression of MGMT through inhibiting the translation of the MGMT mRNA into the MGMT protein in vitro and in vivo. Results showed that MiR (show MLXIP Proteins)-198 induces temozolomide chemosensitivity in glioblastoma by targeting MGMT and that miR (show MLXIP Proteins)-198 may be used as a new diagnostic marker and therapeutic target for glioblastoma in the future.
Alkylating agents have high activity in well-differentiated pancreatic neuroendocrine tumors regardless of MGMT status.
MGMT gene variants are associated with temozolomide myelotoxicity and glioma risk.
Deficient MGMT status in pancreatic neuroendocrine tumors, determined by loss of protein expression or by the presence of MGMT gene promoter methylation is not associated with a better response to temozolomide-based chemotherapy.
MGMT promoter methylation in Epstein-Barr virus-associated oral squamous cell carcinomas
Data show that O(6)-methylguanine-DNA methyltransferase (MGMT) Leu84Phe was significantly related to temozolomide (TMZ) resistance and the prognosis of patients with malignant gliomas.
MGMT promoter methylation was determined by methylation-specific polymerase chain reaction
MGMT methylation is a prognostic factor in newly diagnosed glioblastoma. In this study, we evaluated the rate of change of MGMT methylation during the clinical course of the disease, and we found a significant concordance between the first and the second MGMT methylation assessments, with MGMT methylation being stable in 75% of the cases
Findings show the cell-context dependent effects of PRIMA (show PRIMA1 Proteins)-1MET irrespective of p53 (show TP53 Proteins) status and suggest the role of O6-methylguanine-DNA methyltransferase (MGMT) as a potential molecular target of PRIMA (show PRIMA1 Proteins)-1MET in MGMT-positive glioblastoma stem cell (GSCs).
MGMT methylation assay, of which PSQ appeared to be the best, could improve the predictive power for Glioblastoma patients with MGMT IHC- tumors
Snell, GHKRO, and PAPPA (show PAPPA Proteins)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).
This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (show C16orf35 Proteins), as a key node in determining a carcinogenic threshold.
Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.
Loss of MGMT expression and high Ezrin (show EZR Proteins) protein expression leads to esophageal cancer.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Roles of MGMT and MLH1 (show MLH1 Proteins) proteins in alkylation-induced apoptosis and mutagenesis.
Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer
GAMT (show GAMT Proteins) and AGAT (show GATM Proteins) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (show DMD Proteins) muscle compared to C57
MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
, O6-methylguanine-DNA methyltransferase
, methylated-DNA--protein-cysteine methyltransferase
, methylguanine-DNA methyltransferase
, O-6-alkylguanine-DNA alkyltransferase
, 0-6-methylguanine-DNA methyltransferase
, O(6)-alkylguanine-DNA alkyltransferase
, O6-alkylguanine-DNA alkyltransferase
, O6-methylguanine-DNA methyltranferase