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Human Monoclonal MLH1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689847
Baker, Plug, Prolla, Bronner, Harris, Yao, Christie, Monell, Arnheim, Bradley, Ashley, Liskay: Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. in Nature genetics 1996
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Human Monoclonal MLH1 Primary Antibody for ICC, IHC - ABIN969285
Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). in Familial cancer 2008
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Human Monoclonal MLH1 Primary Antibody for IP, WB - ABIN967392
Prolla, Christie, Liskay: Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. in Molecular and cellular biology 1994
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Human Polyclonal MLH1 Primary Antibody for IHC (p), IP - ABIN151469
Shen, Hu, Jeng, Chang, Lin, Chang, Hsu, Cheng: Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Hamster Monoclonal MLH1 Primary Antibody for IHC (p) - ABIN115274
Pearson, Pinkerton, Lewis, Imeson, Ellershaw, Machin, ,: High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. in The lancet oncology 2008
Results suggest that Xenopus MBD4 (show MBD4 Antibodies)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.
Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.
In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.
Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Antibodies) genes, mlh1, msh2 (show MSH2 Antibodies), and msh6 (show MSH6 Antibodies), in zebrafish that develop tumors at low frequencies.
a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected
radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.
these data identify Mlh1 and Mlh3 (show MLH3 Antibodies) as novel critical genetic modifiers of HTT (show HTT Antibodies) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains
Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.
nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
suggesting a role for the ATPase (show DNAH8 Antibodies) activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Antibodies) partner PMS2 (show PMS2 Antibodies)
Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Antibodies) and brain tumour multicellular spheroids.
MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.
Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Antibodies) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.
Data suggest that the concurrent mutations of the adenomatous polyposis coli protein (APC (show APC Antibodies)) and mutL protein homolog 1 (MLH1) genes probably underline the familial adenomatous polyposis (FAP) in the pedigree.
Among 13 gastric tumors showing no hMLH1 or hMSH2 (show MSH2 Antibodies) expression, 8 MSI (show MSI1 Antibodies)-H (high) and 5 MSI (show MSI1 Antibodies)-L (low) were identified.
Results show that folate concentrations >45.3 nmol/L increased the risk of methylation in specific CpG sites of MLH1.
In contrast to colorectal carcinoma, sporadic MLH1 deficiency is not seen in small bowel adenocarcinoma
MLH1 methylation is associated with colorectal cancer.
We found no correlation between the DLEC1 (show DLEC1 Antibodies), TUSC4 (show NPRL2 Antibodies) and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1 (show DLEC1 Antibodies), TUSC4 (show NPRL2 Antibodies) and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population.
The results of this meta-analysis show a significant association between hMLH1 hypermethylation and colorectal cancer risk.
study to estimate frequency of point mutations and chromosomal rearrangements in 3 mismatch repair (MMR (show MRC1 Antibodies)) genes MLH1, MSH2 (show MSH2 Antibodies), and MSH6 (show MSH6 Antibodies) among unselected patients with ovarian cancer; estimate that approximately 0.6% of unselected ovarian cancer patients have mutations in the MMR (show MRC1 Antibodies) genes
CpG island methylator phenotype (CIMP)+/MLH1-unmethylated (MLH1-U) tumors exhibit aggressive features and are associated with poor clinical outcomes.
Analysis of expression Quantitative Trait Loci (eQTLs) provides modest support for altered regulation of MLH1 and LRRFIP2 (show LRRFIP2 Antibodies), raising the possibility that the modifier affects regulation of both genes.
Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
MutL protein homolog 1
, DNA mismatch repair protein Mlh1
, mutL-like protein 1
, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
, DNA mismatch repair protein Mlh1-like
, colon cancer, nonpolyposis type 2
, mutL protein homolog 1
, mismatch repair protein 1