Protein Summary

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Alternative names and synonyms associated with MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A)

• MRE11 homolog A, double strand break repair nuclease (mre11a) antibody
• MRE11 homolog, double strand break repair nuclease (MRE11) antibody
• MRE11A homolog A, double strand break repair nuclease (Mre11a) antibody
• MRE11 homolog A, double strand break repair nuclease (Mre11a) antibody

• ATLD antibody
• HNGS1 antibody
• MRE11 antibody
• MRE11B antibody
• wu:faa63d12 antibody
• Show all synonym aliases
• zgc:64018 antibody

Protein level used designations for MRE11A

meiotic recombination 11 homolog A , MRE11 meiotic recombination 11 homolog A (S. cerevisiae) , MRE11 homolog 1 , MRE11 homolog A , double-strand break repair protein MRE11A , meiotic recombination 11 homolog 1 , mmMRE11A , AT-like disease , DNA recombination and repair protein , endo/exonuclease Mre11 , meiotic recombination 11-like protein