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anti-Rat (Rattus) NEIL3 Antibodies:
anti-Human NEIL3 Antibodies:
anti-Mouse (Murine) NEIL3 Antibodies:
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This study identifies the NEIL3 promoter possessing a G-rich element that can adopt a G4 fold, and when 8-oxo-7,8-dihydroguanine is incorporated, the sequence can lock into a more stable G4 fold via recruitment of the fifth track of Gs.
Results suggest a novel role for the DNA glycosylase Neil3 in atherogenesis in balancing lipid metabolism and macrophage function, potentially independently of genome-wide canonical base excision repair of oxidative DNA damage.
NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 (show STRN3 Antibodies) phase.
NEIL3-dependent modulation of DNA methylation (show HELLS Antibodies) regulates cardiac fibroblast proliferation and thereby affects extracellular matrix modulation after myocardial infarction.
Data indicate that DNA glycosylases MYH (show MUTYH Antibodies), UNG2 (show CCNO Antibodies), MPG (show MPG Antibodies), NTH1, NEIL1 (show NEIL1 Antibodies), 2 and 3 on nascent DNA.
These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.
SNPs in NEIL3 are associated with impulsivity in Native American sample.
Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption .There was no gender difference for this interaction (P = 0.64 for heterogeneity). NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress.
The abnormal expressions of NEIL1 (show NEIL1 Antibodies), NEIL2 (show NEIL2 Antibodies), and NEIL3 are involved in cancer through their association with the somatic mutation load.
NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction.
Data suggest that neurogenesis induced by Neil3 repair of oxidative DNA damage protects against prion (show PRNP Antibodies) disease during the clinical phase.
one role for Neil3 and NEIL1 (show NEIL1 Antibodies) is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 (show NEIL1 Antibodies) may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
Structural insight into the substrate specificity and marked preference of Neil3 for ssDNA.
Our data support the involvement of Neil3 in removal of replication blocks in proliferating cells.
Neil3-dependent repair of oxidative DNA damage in neural stem/progenitor cells is required for maintenance of adult neurogenesis to counteract the age-associated deterioration of cognitive performance.
Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Delta324), as well as the glycosylase domain of human Neil3 (NEIL3Delta324).
Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002
endonuclease VIII-like 3
, nei like 3
, nei endonuclease VIII-like 3 (E. coli)
, nei endonuclease VIII-like 3
, DNA glycosylase FPG2
, DNA glycosylase hFPG2
, DNA glycosylase/AP lyase Neil3
, endonuclease 8-like 3
, nei-like protein 3